Regenerative Endodontic in Immature Permanent Teeth
Launched by AIN SHAMS UNIVERSITY · Aug 16, 2023
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is looking at two different treatments for children aged 7 to 13 years who have experienced dental trauma that affects their permanent front teeth. Specifically, it compares the use of a special material called demineralized dentin matrix (DDM) to a blood clot for helping the teeth heal when they have a non-vital pulp, which means the nerve inside the tooth is damaged or dead. The goal is to see which treatment leads to better healing over one year.
To participate, children must have at least one front tooth that is still growing and has pulp damage, but the tooth should be restorable. A parent or guardian must agree to the treatment, and the child should not have any serious health issues or allergies to the medications used in the procedure. During the trial, participants will receive the assigned treatment and will be monitored to track their recovery. This study is currently recruiting participants, and it aims to improve the way we treat injured teeth in younger patients.
Gender
ALL
Eligibility criteria
- • Inclusion Criteria : patients clinical examination Must be include the following
- • Patients aged 7-13years at the time of enrolment.
- • Provision of informed consent by one parent or legal guardian.
- • At least the patents have one immature permanent anterior tooth diagnosed with irreversible pulpitis or pulp necrosis with or without periapical lesions.
- • Restorable teeth ,clinical crown should be enough to use rapper dam Compliant patient/parent.
- • Patients are not allergic to medicaments and antibiotics necessary to complete the procedure (ASA 1 or 2).
- • Radiologic evidence of open apices (Teeth are considered immature when a minimum of 0.8 mm apical foramen width is evident)
- * Exclusion Criteria:
- • the patients will excluded if one of the following criteria is present in the patients
- • Teeth with root fractures.
- • Presence of internal or external root resorptions.
- • Developmental anomalies of the root.
- • Presence of periapical radiolucency more than 10 mm.
- • Tooth with class III mobility.
About Ain Shams University
Ain Shams University, established in Cairo, Egypt, is a prestigious higher education institution renowned for its commitment to academic excellence and research innovation. As a clinical trial sponsor, the university leverages its extensive resources and expertise in various medical and scientific disciplines to advance healthcare through rigorous research initiatives. With a focus on ethical practices and adherence to regulatory standards, Ain Shams University aims to contribute to the development of new therapies and improve patient outcomes, fostering collaboration among researchers, healthcare professionals, and industry partners in the pursuit of medical advancements.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Cairo, Alabbassia, Egypt
Patients applied
Trial Officials
nagwa khattab, professor
Study Director
Ain Shams University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported