The Effectiveness of the Letrozole-induced Endometrial Preparation Protocol in Frozen-thawed Embryo Transfer (FET)

Launched by INTERNATIONAL PEACE MATERNITY AND CHILD HEALTH HOSPITAL · Aug 16, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a treatment called the "letrozole-induced endometrial preparation protocol" to see if it helps women who are undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) achieve a successful pregnancy through frozen-thawed embryo transfer (FET). The main goal is to find out if this method increases the chances of a live birth and a clinical pregnancy compared to other methods, such as natural cycles or hormone replacement therapy. The researchers will also look at important factors like the chances of miscarriage, the need to cancel an embryo transfer cycle, and how many visits to the clinic are required.

Women under 40 who have had IVF or ICSI with a certain number of frozen embryos may be eligible to participate. To qualify, they should have had no more than two previous embryo transfers and meet specific health criteria, like not having certain reproductive conditions or a high body mass index. Participants will be randomly assigned to different treatment groups, and they can expect to undergo regular check-ups as part of the study. This research aims to provide important insights that could help improve fertility treatments in the future.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Women \<40 years of age undergoing IVF or ICSI at our reproductive center with a total of ≤3 superovulation cycles , and with ≥2 cleavage embryos or ≥1 blastocyst were cryopreserved. Previous cycles of embryo transfer ≤ 2 and only one transfer cycle with 1-2 embryos per study subject was enrolled.
• Exclusion Criteria:
• • 1. Patients with chromosomal abnormalities in either spouse, hydrosalpinx, severe endometriosis, adenomyosis, and uterine and uterine cavity organic diseases such as uterine malformations, endometrial polyps, and uterine adhesions;
• • 2. patients who underwent pre-implantation genetic diagnosis (PGT);
• • 3. patients who underwent ICSI using surgically obtained epididymal or testicular spermatozoa;
• • 4. patients with a Body mass index (BMI, = weight/height2 ) \> 30 kg/m2;
• • 5. patients with recurrent spontaneous abortions;
• • 6. patients with sequential embryo transfer.