A Multiomics Study Based on the Dynamic Evolution of Endometrial Carcinogenesis

Launched by RENJI HOSPITAL · Aug 17, 2023

Keywords

ClinConnect Summary

This clinical trial is researching how endometrial cancer, a type of cancer that affects the lining of the uterus, develops over time. The study aims to understand the changes in different biological factors, such as genes and proteins, in women with normal endometrial tissue, those with atypical hyperplasia (a condition that can lead to cancer), and women who already have endometrial cancer. By examining these changes in 300 women, the researchers hope to uncover the underlying mechanisms of how this type of cancer forms and evolves.

To participate in this study, women aged 65 to 74 who have been diagnosed with either normal endometrium, atypical hyperplasia, or endometrial cancer may be eligible, as long as they have had surgery to confirm their diagnosis and are willing to provide their health information for research. Participants will need to sign a consent form and agree to some tests that analyze their biological samples. It's important to note that this study is not yet recruiting participants, but it will provide valuable insights into endometrial cancer and may help improve future treatments.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Pathological diagnosis: normal endometrium, atypical hyperplasia endometrium, or endometrial cancer;
• • Obtain pathological results after undergoing hysteroscopic surgery or hysterectomy;
• • The patient voluntarily participated in this research project with good compliance and was able to complete the enrollment according to the experimental requirements;
• • Sign the informed consent form and consent to the collection and use of their data, and consent to genomics, transcriptome and other tests.
• Exclusion Criteria:
• • Patients with malignant tumors in other parts of the body;
• • Suffering from uncontrollable neurological diseases, psychiatric diseases, or psychiatric disorders;
• • Poor compliance and inability to cooperate and describe treatment responders.