Understanding Metabolism and Inflammation Risks for Diabetes in Adolescents
Launched by UNIVERSITY OF MICHIGAN · Aug 17, 2023
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is looking to understand how body weight, lifestyle, and diet affect certain immune cells that may play a role in diabetes among teenagers. The study aims to find out if adolescents at risk for metabolic diseases, like insulin resistance and type 2 diabetes, have increased activity of these immune cells. By collecting health information and blood samples, researchers hope to learn more about these connections and how they might help improve future treatments.
To participate in this study, teens aged 14 to 18 who are either at a normal weight, obese, or have pre-diabetes or type 2 diabetes may qualify. Participants will have the opportunity to undergo health assessments and provide blood samples, which can help researchers understand more about diabetes in young people. It's important to note that pregnant teens, those taking certain medications, or with specific health conditions may not be eligible. Overall, this study aims to gain insights that could lead to better management strategies for diabetes in adolescents.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Between 14 and 18 years of age
- • Tanner stage 4 or 5 (mature adult stage of puberty)
- • Normal weight (BMI ≥ 5th percentile \& \< 85th percentile), overweight (BMI \> 86th percentile) \& \< 94th percentile), obese weight (BMI percentile ≥ 95th percentile), and/or pre-diabetes (HbA1c \> 5.7%)
- • For Type 2 Diabetes cohort, diagnosis of Type 2 Diabetes
- Exclusion Criteria:
- • Currently pregnant
- • Use medications known to affect glucose metabolism (immunosuppressive medications, cancer medications, or high dose steroids), unless prescribed for Type 2 Diabetes management
- • Prior diagnosis of autoimmune disease, cancer, or a cognitive or perceptual disability that would inhibit following directions of study staff
- • Allergies or intolerance to milk, soy, or palm oil
About University Of Michigan
The University of Michigan, a leading academic institution renowned for its commitment to advancing healthcare and medical research, serves as a prominent clinical trial sponsor. With a robust infrastructure that supports innovative research initiatives, the university leverages its multidisciplinary expertise to conduct a wide array of clinical trials aimed at improving patient outcomes and advancing medical knowledge. Through its state-of-the-art facilities and collaborative environment, the University of Michigan fosters partnerships between researchers, clinicians, and industry leaders, ensuring the development of cutting-edge therapies and interventions that address pressing health challenges.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Ann Arbor, Michigan, United States
Ann Arbor, Michigan, United States
Patients applied
Trial Officials
Kanakadurga Singer, MA, MD
Principal Investigator
University of Michigan
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported