Enlicitide Decanoate (MK-0616 Oral PCSK9 Inhibitor) Cardiovascular Outcomes Study (MK-0616-015) CORALreef Outcomes
Launched by MERCK SHARP & DOHME LLC · Aug 17, 2023
Trial Information
Current as of June 27, 2025
Recruiting
Keywords
ClinConnect Summary
The CORALreef study is a clinical trial that is looking at a new medication called enlicitide decanoate, which is an oral treatment designed to help lower cholesterol and reduce the risk of serious heart problems. This study is specifically for adults who have a high risk of heart issues, such as those with a history of heart attacks or strokes, or those with certain conditions like diabetes or high cholesterol levels. Participants will be randomly assigned to receive either the new medication or a placebo (which looks like the medication but has no active ingredients) to see if it helps prevent major heart events like heart attacks or strokes.
To be eligible for this trial, participants need to be at least 18 years old and have a history of serious heart disease or be at high risk for developing it. They should also be on stable cholesterol-lowering medications for at least 30 days before joining the study. Throughout the trial, participants will have regular check-ups to monitor their health and how they respond to the treatment. It’s important to know that this trial is currently recruiting participants, and everyone involved will help researchers understand whether this new treatment can make a difference in preventing heart-related problems.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- * Meets one of the following:
- • 1. Age ≥18 years with a history of a major atherosclerotic cardiovascular disease (ASCVD) event defined as at least 1 of the following: ≥30 days post MI (presumed Type 1 due to plaque rupture or erosion); ≥30 days post ischemic stroke (presumed due to atherosclerosis); or ≥30 days post successful peripheral (carotid or lower extremity) arterial revascularization (surgical or endovascular) or major (ankle or above) amputation due to atherosclerosis; or
- • 2. High risk for first major ASCVD event defined as at least 1 of the following: Age ≥50 years with evidence of coronary artery disease; Age ≥50 years with evidence of atherosclerotic cerebrovascular disease; Age ≥50 years with evidence of peripheral arterial disease; or Age ≥60 years with diabetes mellitus and at least one of the following: microvascular disease or urine albumin-creatinine ratio ≥30 mg/mmol within 6 months before Visit 1, daily insulin use, or diabetes for ≥10 years
- * Has fasted lipid values (evaluated by the Central Laboratory) at Visit 1 (Screening) as follows:
- • 1. History of major ASCVD Event: LDL-C ≥70 mg/dL (1.81 mmol/L) OR non-HDL-C ≥100 mg/dL (2.59 mmol/L)
- • 2. High risk for first major ASCVD Event: LDL-C ≥90 mg/dL (2.33 mmol/L) OR non-HDL-C ≥120 mg/dL (3.11 mmol/L)
- • Is treated with moderate- or high-intensity statin (± nonstatin lipid-lowering therapy \[LLT\]) at Visit 1
- • Is on a stable dose of all background LLTs (including statin and nonstatin agents) for at least 30 days before Visit 1 (Screening) with no medication or dose changes planned during the participation in the study
- Exclusion Criteria:
- • Has a history of homozygous familial hypercholesterolemia (FH) based on genetic or clinical criteria, compound heterozygous FH, or double heterozygous FH
- • Has New York Heart Association Class IV heart failure, last known Left Ventricular Ejection Fraction ≤25% by any imaging method, or had a Heart Failure hospitalization within 3 months before Visit 1 (Screening)
- • Has recurrent ventricular tachycardia within 3 months prior to randomization
- • Has a planned arterial revascularization procedure
- • Is undergoing or previously underwent an LDL-C apheresis program within 3 months before Visit 1 (Screening) or plans to initiate an LDL-C apheresis program
- • Was previously treated/is being treated with certain other cholesterol lowering medications, including protein convertase subtilisin/kexin type 9 (PCSK9) inhibitors without adequate washout.
- • Has a fasting triglyceride value ≥400 mg/dL (≥4.52 mmol/L) at Visit 1 (Screening)
About Merck Sharp & Dohme Llc
Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc., is a leading global biopharmaceutical company dedicated to discovering, developing, and delivering innovative medicines and vaccines that address unmet medical needs. With a strong focus on research and development, Merck Sharp & Dohme leverages advanced science and technology to enhance patient outcomes across various therapeutic areas, including oncology, infectious diseases, and cardiovascular health. Committed to ethical practices and regulatory compliance, the company actively engages in clinical trials to advance medical knowledge and improve health care for patients worldwide.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Taipei, , Taiwan
Merida, Yucatan, Mexico
Gdynia, Pomorskie, Poland
Aurora, Colorado, United States
Louisville, Kentucky, United States
Albuquerque, New Mexico, United States
West Jordan, Utah, United States
North Charleston, South Carolina, United States
Manassas, Virginia, United States
Changhua County, Changhua, Taiwan
Taipei, , Taiwan
Chicoutimi, Quebec, Canada
Ramat Gan, , Israel
Rotorua, Bay Of Plenty, New Zealand
Pok Fu Lam, , Hong Kong
Shatin, , Hong Kong
Christchurch, Canterbury, New Zealand
Caba, Buenos Aires, Argentina
Ciudad Autónoma De Buenos Aires, Buenos Aires, Argentina
Mar Del Plata, Buenos Aires, Argentina
Ciudad Autonoma De Buenos Aires, Caba, Argentina
Buenos Aires, , Argentina
Jerusalem, , Israel
Seongnam, Kyonggi Do, Korea, Republic Of
Suwon, Kyonggi Do, Korea, Republic Of
Busan, Pusan Kwangyokshi, Korea, Republic Of
Daegu, Taegu Kwangyokshi, Korea, Republic Of
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Seoul, , Korea, Republic Of
Taipei, , Taiwan
Altindağ, Ankara, Turkey
Ankara, , Turkey
Eskisehir, , Turkey
Phoenix, Arizona, United States
Lake City, Florida, United States
Winter Park, Florida, United States
Woodstock, Georgia, United States
Chicago, Illinois, United States
Gurnee, Illinois, United States
Troy, Michigan, United States
Gulfport, Mississippi, United States
Hazelwood, Missouri, United States
Lincoln, Nebraska, United States
Yardley, Pennsylvania, United States
Buenos Aires, , Argentina
Blacktown, New South Wales, Australia
Kanwal, New South Wales, Australia
Seoul, , Korea, Republic Of
Valdivia, Los Rios, Chile
Santiago, Region M. De Santiago, Chile
Tarnów, Malopolskie, Poland
Rapid City, South Dakota, United States
Kaohsiung Niao Sung Dist, Kaohsiung, Taiwan
Kocaeli, , Turkey
Clayton, Victoria, Australia
Medellín, Antioquia, Colombia
Barranquilla, Atlantico, Colombia
Barranquilla, Atlantico, Colombia
Bogotá, Cundinamarca, Colombia
Birmingham, Alabama, United States
Daphne, Alabama, United States
Beverly Hills, California, United States
Tarzana, California, United States
Waterbury, Connecticut, United States
Washington, District Of Columbia, United States
Boca Raton, Florida, United States
Cutler Bay, Florida, United States
Fort Myers, Florida, United States
Jacksonville, Florida, United States
Jacksonville, Florida, United States
Jacksonville, Florida, United States
Miami, Florida, United States
Miramar, Florida, United States
Ocala, Florida, United States
Saint Augustine, Florida, United States
Macon, Georgia, United States
Chicago, Illinois, United States
Flossmoor, Illinois, United States
Topeka, Kansas, United States
Wichita, Kansas, United States
Lexington, Kentucky, United States
Crowley, Louisiana, United States
Monroe, Louisiana, United States
Boston, Massachusetts, United States
Grand Rapids, Michigan, United States
Kansas City, Missouri, United States
Elkhorn, Nebraska, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Binghamton, New York, United States
Manlius, New York, United States
New Windsor, New York, United States
Rochester, New York, United States
Rosedale, New York, United States
Fargo, North Dakota, United States
Cincinnati, Ohio, United States
Camp Hill, Pennsylvania, United States
Kingsport, Tennessee, United States
Knoxville, Tennessee, United States
Houston, Texas, United States
Pearland, Texas, United States
San Antonio, Texas, United States
San Antonio, Texas, United States
Sugar Land, Texas, United States
Salt Lake City, Utah, United States
Salt Lake City, Utah, United States
Charlottesville, Virginia, United States
Suffolk, Virginia, United States
Buenos Aires, Caba, Argentina
Bruce, Australian Capital Territory, Australia
Rio De Janeiro, , Brazil
Kelowna, British Columbia, Canada
Cambridge, Ontario, Canada
Toronto, Ontario, Canada
Jerusalem, , Israel
Kamakura, Kanagawa, Japan
Akishima, Tokyo, Japan
Zárate, Buenos Aires, Argentina
Tainan City, Tainan, Taiwan
Montreal, Quebec, Canada
Petah Tikva, , Israel
Birmingham, Alabama, United States
Foley, Alabama, United States
Toluca Lake, California, United States
Washington, District Of Columbia, United States
Miami Lakes, Florida, United States
Port Orange, Florida, United States
Evansville, Indiana, United States
Anderson, South Carolina, United States
Bristol, Tennessee, United States
Newport News, Virginia, United States
Norfolk, Virginia, United States
Rosario, Santa Fe, Argentina
Brasilia, Distrito Federal, Brazil
Goiania, Goias, Brazil
Campina Grande Do Sul, Parana, Brazil
Votuporanga, Sao Paulo, Brazil
Aracaju, Sergipe, Brazil
Oakville, Ontario, Canada
Trois Rivieres, Quebec, Canada
Temuco, Araucania, Chile
Talca, Maule, Chile
Providencia, Region M. De Santiago, Chile
Santiago, Region M. De Santiago, Chile
Santiago, Region M. De Santiago, Chile
Santiago, Region M. De Santiago, Chile
Santiago, Region M. De Santiago, Chile
ñuñoa, Region M. De Santiago, Chile
Viña Del Mar, Valparaiso, Chile
Shatin, , Hong Kong
Ashkelon, , Israel
Haifa, , Israel
Haifa, , Israel
Kasuga, Fukuoka, Japan
Takamatsu Shi, Kagawa, Japan
Uji, Kyoto, Japan
Hachioji, Tokyo, Japan
Higashiyamato Shi, Tokyo, Japan
Tauranga, Bay Of Plenty, New Zealand
Petah Tikva, , Israel
Hadera, , Israel
Jerusalem, , Israel
Alexander City, Alabama, United States
Lancaster, California, United States
Los Angeles, California, United States
Kansas City, Kansas, United States
Winston Salem, North Carolina, United States
Santa Fe, , Argentina
Fortaleza, Ceara, Brazil
Bragança Paulista, Sao Paulo, Brazil
North York, Ontario, Canada
Kumamoto, , Japan
Indianapolis, Indiana, United States
Maplewood, Minnesota, United States
Lanus, Buenos Aires, Argentina
Porto Alegre, Rio Grande Do Sul, Brazil
Santiago, Region M. De Santiago, Chile
Hksar, , Hong Kong
Be'er Sheva, , Israel
Hanyu, Saitama, Japan
Pasadena, California, United States
Tomball, Texas, United States
Burke, Virginia, United States
Falls Church, Virginia, United States
Buenos Aires, Caba, Argentina
Canoas, Rio Grande Do Sul, Brazil
Porto Alegre, Rio Grande Do Sul, Brazil
Campinas, Sao Paulo, Brazil
São Paulo, Sao Paulo, Brazil
Torrance, California, United States
Odessa, Texas, United States
La Plata, Buenos Aires, Argentina
Ramos Mejía, Buenos Aires, Argentina
Rosario, Santa Fe, Argentina
Rosario, Santa Fe, Argentina
Santa Fe, , Argentina
Camperdown, New South Wales, Australia
Campo Largo, Parana, Brazil
Porto Alegre, Rio Grande Do Sul, Brazil
São José Do Rio Preto, Sao Paulo, Brazil
São Paulo, Sao Paulo, Brazil
Cambridge, Ontario, Canada
Haifa, , Israel
Herzliya, , Israel
Sakhnin, , Israel
Saitama, , Japan
Christchurch, Canterbury, New Zealand
Palmerston North, Manawatu Wanganui, New Zealand
Auckland, , New Zealand
New Taipei City, New Taipei, Taiwan
Taichung, , Taiwan
Zipaquira, Cundinamarca, Colombia
Cali, Valle Del Cauca, Colombia
San Mateo, California, United States
Cutler Bay, Florida, United States
Okayama, , Japan
Nawton, Waikato, New Zealand
Ebdentown, Wellington, New Zealand
Auckland, , New Zealand
Nelson, , New Zealand
Taipei, , Taiwan
Bornova, Izmir, Turkey
Dresden, Sachsen, Germany
Rome, Lazio, Italy
Milan, Milano, Italy
Santiago De Compostela, La Coruna, Spain
Valencia, Valenciana, Comunitat, Spain
Torino, Piemonte, Italy
Pozuelo De Alarcón, Madrid, Spain
Stamford, Connecticut, United States
Fort Wayne, Indiana, United States
San Nicolas, Buenos Aires, Argentina
Terrebonne, Quebec, Canada
Beijing, Beijing, China
Foshan, Guangdong, China
Guangzhou, Guangdong, China
Huizhou, Guangdong, China
Shenzhen, Guangdong, China
Guiyang, Guizhou, China
Daqing, Heilongjiang, China
Nanyang, Henan, China
Wuhan, Hubei, China
Nanjing, Jiangsu, China
Zhenjiang, Jiangsu, China
Pingxiang, Jiangxi, China
Linyi, Shandong, China
Shanghai, Shanghai, China
Chengdu, Sichuan, China
Chengdu, Sichuan, China
Suining, Sichuan, China
Linhai, Zhejiang, China
Holon, , Israel
Himeji, Hyogo, Japan
Takamatsu, Kagawa, Japan
ōmura, Nagasaki, Japan
Fukuoka, , Japan
Nagasaki, , Japan
Saitama, , Japan
Tokyo, , Japan
Seoul, , Korea, Republic Of
Taipei, , Taiwan
Bristol, Bristol, City Of, United Kingdom
London, England, United Kingdom
Clydebank, Glasgow City, United Kingdom
Corby, Northamptonshire, United Kingdom
Milan, Milano, Italy
Castilleja De La Cuesta, Sevilla, Spain
La Jolla, California, United States
Littleton, Colorado, United States
Dearborn, Michigan, United States
Bridgewater, New Jersey, United States
Washington Township, New Jersey, United States
Dayton, Ohio, United States
Manassas, Virginia, United States
San Nicolas, Buenos Aires, Argentina
Córdoba, Cordoba, Argentina
Guangzhou, Guangdong, China
Haikou, Hainan, China
Changsha, Hunan, China
Changsha, Hunan, China
Siping, Jilin, China
Shenyang, Liaoning, China
Medellín, Antioquia, Colombia
Medellín, Antioquia, Colombia
Barranquilla, Atlantico, Colombia
Manizales, Caldas, Colombia
Valledupar, Cesar, Colombia
Bogotá, Cundinamarca, Colombia
Bogotá, Cundinamarca, Colombia
Piedecuesta, Santander, Colombia
Ibague, Tolima, Colombia
Shatin, , Hong Kong
Shatin, , Hong Kong
Fujisawa, Kanagawa, Japan
Saga Shi, Saga, Japan
Fukuoka, , Japan
Hadera, , Israel
Taipei, , Taiwan
Jacksonville, Florida, United States
Oklahoma City, Oklahoma, United States
Chongqing, Chongqing, China
Wanzhou, Chongqing, China
Jiangmen, Guangdong, China
Changsha, Hunan, China
Yueyang, Hunan, China
Bao Tou, Inner Mongolia, China
Chifeng, Inner Mongolia, China
Yangzhou, Jiangsu, China
Nanchang, Jiangxi, China
Yinchuan, Ningxia, China
Xi'an, Shaanxi, China
Montería, Cordoba, Colombia
Bogota, Cundinamarca, Colombia
Cali, Valle Del Cauca, Colombia
Antalya, , Turkey
Edirne, , Turkey
Exeter, Devon, United Kingdom
Newcastle Upon Tyne, , United Kingdom
Sheffield, , United Kingdom
Petah Tikva, , Israel
Bangor, Maine, United States
New Hyde Park, New York, United States
Hefei, Anhui, China
Beijing, Beijing, China
Wanzhou, Chongqing, China
Qiqihar, Heilongjiang, China
Hohhot, Inner Mongolia, China
Changzhou, Jiangsu, China
Changchun, Jilin, China
Xianyang, Shaanxi, China
Xian, Shaanxi, China
Zibo, Shandong, China
Shanghai, Shanghai, China
Shanghai, Shanghai, China
Neijiang, Sichuan, China
Tianjin, Tianjin, China
Lishui City, Zhejiang, China
Petah Tikva, , Israel
Matsudo, Chiba, Japan
Fukuoka, , Japan
Ciudad De México, Distrito Federal, Mexico
Mexico City, Distrito Federal, Mexico
Guadalajara, Jalisco, Mexico
Guadalajara, Jalisco, Mexico
Monterrey, Nuevo Leon, Mexico
Aguascalientes, , Mexico
Chihuahua, , Mexico
Veracruz, , Mexico
Arequipa, Ariqipa, Peru
Trujillo, La Libertad, Peru
Miraflores, Muni Metro De Lima, Peru
Lima, , Peru
Lima, , Peru
Lima, , Peru
Lima, , Peru
Lima, , Peru
Lima, , Peru
Piura, , Peru
Piura, , Peru
Walsall, , United Kingdom
Tupelo, Mississippi, United States
New York, New York, United States
Zanesville, Ohio, United States
Chongqing, Chongqing, China
Harbin, Heilongjiang, China
Nagoya, Aichi, Japan
Itoshima, Fukuoka, Japan
Nakagawa, Fukuoka, Japan
Osaka, , Japan
Mexico City, Distrito Federal, Mexico
Monterrey, Nuevo Leon, Mexico
Ciudad Madero, Tamaulipas, Mexico
Aguascalientes, , Mexico
Port Elizabeth, Eastern Cape, South Africa
Bloemfontein, Free State, South Africa
Johannesburg, Gauteng, South Africa
Johannesburg, Gauteng, South Africa
Midrand, Gauteng, South Africa
Moloto, Gauteng, South Africa
Pretoria West, Gauteng, South Africa
Pretoria, Gauteng, South Africa
Bellville, Cape Town, Western Cape, South Africa
Cape Town, Western Cape, South Africa
Cape Town, Western Cape, South Africa
George, Western Cape, South Africa
Paarl, Western Cape, South Africa
Paarl, Western Cape, South Africa
Worcester, Western Cape, South Africa
Melikgazi, Kayseri, Turkey
La Plata, Buenos Aires, Argentina
Buenos Aires, Caba, Argentina
Santa Fe, , Argentina
Chongqing, Chongqing, China
Chongqing, Chongqing, China
Wuhan, Hubei, China
Zhenjiang, Jiangsu, China
Taiyuan, Shaanxi, China
Nagoya, Aichi, Japan
Tsukuba, Ibaraki, Japan
Kuse Gun Kumiyama Cho, Kyoto, Japan
Kyoto, , Japan
Daegu, Taegu Kwangyokshi, Korea, Republic Of
Zapopan, Jalisco, Mexico
Aguascalientes, , Mexico
Veracruz, , Mexico
Lørenskog, Akershus, Norway
Bergen, Hordaland, Norway
Bodø, Nordland, Norway
Oslo, , Norway
Oslo, , Norway
Madrid, Madrid, Comunidad De, Spain
El Palmar, Murcia, Murcia, Region De, Spain
Karsiyaka, Izmir, Turkey
Konya, , Turkey
Manchester, , United Kingdom
Boston, Massachusetts, United States
Gandrup, Nordjylland, Denmark
Hjorring, Nordjylland, Denmark
Slagelse, Sjaelland, Denmark
Svendborg, Syddanmark, Denmark
Debrecen, Hajdu Bihar, Hungary
Nyíregyháza, Borbánya, Szabolcs Szatmar Bereg, Hungary
Budapest, , Hungary
Debrecen, , Hungary
Zalaegerszeg, , Hungary
Rotterdam, Aruba, Netherlands
Hoogeveen, Drenthe, Netherlands
Sneek, Fryslan, Netherlands
Apeldoorn, Gelderland, Netherlands
Harderwijk, Gelderland, Netherlands
Nijmegen, Gelderland, Netherlands
Tiel, Gelderland, Netherlands
Zutphen, Gelderland, Netherlands
Venlo, Limburg, Netherlands
Roosendaal, Noord Brabant, Netherlands
Amstelveen, Noord Holland, Netherlands
Amsterdam, Noord Holland, Netherlands
Amsterdam, Noord Holland, Netherlands
Amersfoort, Utrecht, Netherlands
Goes, Zeeland, Netherlands
Dordrecht, Zuid Holland, Netherlands
Gouda, Zuid Holland, Netherlands
Leiderdorp, Zuid Holland, Netherlands
Oslo, , Norway
Malaga, Andalucia, Spain
Sevilla, Andalucia, Spain
Barcelona, Cataluna, Spain
Alcorcón, Madrid, Comunidad De, Spain
Madrid, Madrid, Comunidad De, Spain
Majadahonda, Madrid, Comunidad De, Spain
Melikgazi, Kayseri, Turkey
Miami, Florida, United States
Suffolk, Virginia, United States
Wanzhou, Chongqing, China
Wuhan, Hubei, China
Xuzhou, Jiangsu, China
Tianjin, Tianjin, China
Herlev, Hovedstaden, Denmark
Esbjerg, Syddanmark, Denmark
Vejle, Syddanmark, Denmark
Orléans, Centre, France
Dijon, Cote D Or, France
Rennes, Ille Et Vilaine, France
Reims, Marne, France
Valenciennes, Nord, France
Bad Friedrichshall, Baden Wurttemberg, Germany
Mannheim, Baden Wurttemberg, Germany
Nuremberg, Bayern, Germany
Bad Nauheim, Hessen, Germany
Frankfurt Am Main, Hessen, Germany
Frankfurt, Hessen, Germany
Hannover, Niedersachsen, Germany
Stuhr, Niedersachsen, Germany
Bielefeld, Nordrhein Westfalen, Germany
Cologne, Nordrhein Westfalen, Germany
Essen, Nordrhein Westfalen, Germany
Essen, Nordrhein Westfalen, Germany
Essen, Nordrhein Westfalen, Germany
Witten, Nordrhein Westfalen, Germany
Kaiserslautern, Rheinland Pfalz, Germany
Völklingen, Saarland, Germany
Hohenmölsen, Sachsen Anhalt, Germany
Leipzig, Sachsen, Germany
Berlin, , Germany
Berlin, , Germany
Berlin, , Germany
Hamburg, , Germany
Wong Tai Sin, , Hong Kong
Baja, Bacs Kiskun, Hungary
Békéscsaba, Bekes, Hungary
Szeged, Csongrad, Hungary
Pécs, Pecs, Hungary
Kaposvár, Somogy, Hungary
Balatonfüred, Veszprem, Hungary
Budapest, , Hungary
Budapest, , Hungary
Budapest, , Hungary
Majd Al Krum, , Israel
Rehovot, , Israel
Naples, Campania, Italy
Roma, Lazio, Italy
Pavia, , Italy
Torino, , Italy
Toyota, Aichi, Japan
Sapporo, Hokkaido, Japan
Okayama, , Japan
Mexico, Distrito Federal, Mexico
León, Guanajuato, Mexico
Pachuca, Hidalgo, Mexico
Guadalajara, Jalisco, Mexico
Cuauhtemoc, , Mexico
Mexico, , Mexico
Oaxaca, , Mexico
Oaxaca, , Mexico
Emmen, Drenthe, Netherlands
Leeuwarden, Fryslan, Netherlands
Breda, Noord Brabant, Netherlands
Eindhoven, Noord Brabant, Netherlands
Hilversum, Noord Holland, Netherlands
Almelo, Overijssel, Netherlands
Delft, Zuid Holland, Netherlands
Den Haag, Zuid Holland, Netherlands
Leiden, Zuid Holland, Netherlands
Lorenskog, Akershus, Norway
Lillehammer, Oppland, Norway
Lima, , Peru
Legnica, Dolnoslaskie, Poland
Bydgoszcz, Kujawsko Pomorskie, Poland
Bydgoszcz, Kujawsko Pomorskie, Poland
Torun, Kujawsko Pomorskie, Poland
Zgierz, Lodzkie, Poland
Lublin, Lubelskie, Poland
Chrzanow, Malopolskie, Poland
Kraków, Malopolskie, Poland
Tarnow, Malopolskie, Poland
Warsaw, Mazowieckie, Poland
Warszawa, Mazowieckie, Poland
Rzeszow, Podkarpackie, Poland
Bialystok, Podlaskie, Poland
Gdańsk, Pomorskie, Poland
Gdynia, Pomorskie, Poland
Bielsko Biala, Slaskie, Poland
Dabrowa Gornicza, Slaskie, Poland
Katowice, Slaskie, Poland
Katowice, Slaskie, Poland
Elblag, Warminsko Mazurskie, Poland
Poznan, Wielkopolskie, Poland
Poznań, Wielkopolskie, Poland
Johannesburg, Gauteng, South Africa
Pretoria, Gauteng, South Africa
Durban, Kwazulu Natal, South Africa
Durban, Kwazulu Natal, South Africa
George, Western Cape, South Africa
Plettenberg Bay, Western Cape, South Africa
Centelles, Cataluna, Spain
Madrid, , Spain
Madrid, , Spain
Tarragona, , Spain
Istanbul, , Turkey
Malatya, , Turkey
Durham, North Carolina, United States
Harbin, Heilongjiang, China
Jinzhou, Liaoning, China
Le Coudray, Eure Et Loir, France
Nîmes, Gard, France
Saint Priest En Jarez, Loire, France
Pau, Pyrenees Atlantiques, France
Grenoble, Rhone Alpes, France
Wallerfing, Bayern, Germany
Dortmund, Nordrhein Westfalen, Germany
Dresden, Sachsen, Germany
Hamburg, , Germany
Budapest, , Hungary
Nahariya, , Israel
Osaka, , Japan
Alkmaar, Noord Holland, Netherlands
Bellavista, Qallaw, Peru
Lodz, Lodzkie, Poland
Skierniewice, Lodzkie, Poland
Torrevieja, Alicante, Spain
León, Leon, Spain
València, Valencia, Spain
Beverly Hills, California, United States
Cleveland, Ohio, United States
Hoppers Crossing, Victoria, Australia
Nanchang, Jiangxi, China
Hangzhou, Zhejiang, China
Copenhagen, Hovedstaden, Denmark
Aarhus, Midtjylland, Denmark
Herning, Midtjylland, Denmark
Roskilde, Sjaelland, Denmark
Limoges, Haute Vienne, France
Pau, Pyrenees Atlantiques, France
Poitiers, Vienne, France
Heidelberg, Baden Wurttemberg, Germany
Berlin, , Germany
Budapest, Zala, Hungary
Lecco, , Italy
Toyota, Aichi, Japan
Kitakyushu, Fukuoka, Japan
Isehara, Kanagawa, Japan
Kumamoto, , Japan
Osaka, , Japan
Ede, Gelderland, Netherlands
Helmond, Noord Brabant, Netherlands
Amsterdam, Noord Holland, Netherlands
Zaandam, Noord Holland, Netherlands
Alesund, More Og Romsdal, Norway
Oslo, , Norway
La Perla Callao, Lima, Peru
Tychy, Slaskie, Poland
Zabrze, Slaskie, Poland
Bayamon, , Puerto Rico
Newcastle Upon Tyne, England, United Kingdom
Brisbane, Queensland, Australia
Paris, Orne, France
Berlin, , Germany
Roma, Lazio, Italy
Parma, , Italy
Mexico City, Distrito Federal, Mexico
Veracruz, , Mexico
Emmen, Drenthe, Netherlands
Hoorn, Noord Holland, Netherlands
Rotterdam, Zuid Holland, Netherlands
Dunedin, Otago, New Zealand
Wellington, , New Zealand
Grodzisk Mazowiecki, Mazowieckie, Poland
Humacao, , Puerto Rico
Ponce, , Puerto Rico
Johannesburg, Gauteng, South Africa
Cordoba, Andalucia, Spain
Calella, Barcelona, Spain
Lincoln, Nebraska, United States
Concepcion, Biobio, Chile
Dresden, Sachsen, Germany
Cona, Ferrara, Italy
Monza, Monza E Brianza, Italy
Palermo, Sicilia, Italy
General Escobedo, Nuevo Leon, Mexico
Monterrey, Nuevo Leon, Mexico
Hastings, Hawkes Bay, New Zealand
Lower Hutt, Wellington, New Zealand
Adana, , Turkey
Canakkale, , Turkey
Bristol, Bristol, City Of, United Kingdom
Romford, London, City Of, United Kingdom
Leicester, , United Kingdom
Quillota, Valparaiso, Chile
Brescia, Lombardia, Italy
Groningen, , Netherlands
L'hospitalet De Llobregat, Cataluna, Spain
Walsall, Devon, United Kingdom
Buenos Aires, , Argentina
Porto Alegre, Rio Grande Do Sul, Brazil
Temuco, Araucania, Chile
Chambray Les Tours, Centre, France
Szekesfehervar, Fejer, Hungary
Roma, Lazio, Italy
Auckland, , New Zealand
San Juan, , Puerto Rico
Madrid, , Spain
México, Distrito Federal, Mexico
Doetinchem, Gelderland, Netherlands
Kaohsiung, , Taiwan
Blackfoot, Idaho, United States
Columbia, Maryland, United States
Columbus, Ohio, United States
Sayre, Pennsylvania, United States
Amarillo, Texas, United States
Austin, Texas, United States
Caba, Buenos Aires, Argentina
Corrientes, , Argentina
Guangzhou, Guangdong, China
Bergamo, Lombardia, Italy
Tauranga, Bay Of Plenty, New Zealand
Palmerston North, Manawatu Wanganui, New Zealand
Auckland, , New Zealand
Warszawa, Mazowieckie, Poland
Ankara, , Turkey
Istanbul, , Turkey
Birmingham, Alabama, United States
Glendale, Arizona, United States
Little Rock, Arkansas, United States
Park Ridge, Illinois, United States
Bowie, Maryland, United States
Boston, Massachusetts, United States
Lincoln, Nebraska, United States
Grand Forks, North Dakota, United States
Dallas, Texas, United States
Tomball, Texas, United States
Waco, Texas, United States
Caba, , Argentina
Qiqihar, Heilongjiang, China
Barranquilla, Atlantico, Colombia
Montauban, Tarn Et Garonne, France
Napoli, , Italy
Kumamoto, , Japan
Ciudad De Mexico, Distrito Federal, Mexico
Sopot, Pomorskie, Poland
Soweto, Gauteng, South Africa
Samsun, , Turkey
Mar Del Plata., Buenos Aires, Argentina
Santiago, Region M. De Santiago, Chile
Rotterdam, Zuid Holland, Netherlands
łódź, Lodzkie, Poland
Zabrze, Slaskie, Poland
Taipei, , Taiwan
Richmond, Indiana, United States
Quebec, , Canada
Santa Fe., Santa Fe, Argentina
Chengdu, Sichuan, China
Higashiyamato, Tokyo, Japan
Durban, Kwazulu Natal, South Africa
Ypsilanti, Michigan, United States
Minneapolis, Minnesota, United States
Columbus, Ohio, United States
Caba, Buenos Aires, Argentina
Concepcion., Biobio, Chile
Santiago., Region M. De Santiago, Chile
Jiangmen, Guangdong, China
Neijiang, Sichuan, China
Tijuana, Baja California, Mexico
Lima, , Peru
Grodzisk Mazowiecki, Mazowieckie, Poland
New Taipei City, New Taipei, Taiwan
Quillota, Valparaiso, Chile
Monteria, Cordoba, Colombia
Foshan, Guangdong, China
Nelson, , New Zealand
Lima, , Peru
Aurora, Colorado, United States
Rapid City, South Dakota, United States
Terrebonne, Quebec, Canada
Dresden, Sachsen, Germany
Roma, Lazio, Italy
Guadalajara, Jalisco, Mexico
Zapopan, Jalisco, Mexico
Merida, Yucatan, Mexico
Tarnów, Malopolskie, Poland
Warszawa, Mazowieckie, Poland
Gdynia, Pomorskie, Poland
Minneapolis, Minnesota, United States
Santo Andre, Sao Paulo, Brazil
Rehovot, , Israel
Changhua, , Taiwan
Newcastle Upon Tyne, England, United Kingdom
Johannesburg, Gauteng, South Africa
Valencia, , Spain
Alcorcón, , Spain
Madrid, , Spain
Madrid, , Spain
Majadahonda, , Spain
El Palmar, Murcia, , Spain
Bristol, , United Kingdom
Bristol, , United Kingdom
Romford, , United Kingdom
Patients applied
Trial Officials
Medical Director
Study Director
Merck Sharp & Dohme LLC
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported