Inflammation and Coagulation Factors for Predicting Cerebral Edema After SAH

Launched by SECOND AFFILIATED HOSPITAL, SCHOOL OF MEDICINE, ZHEJIANG UNIVERSITY · Aug 22, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how inflammation and blood clotting factors in the fluid around the brain can help predict whether patients will experience persistent swelling in the brain (known as cerebral edema) after a specific type of bleeding in the brain called subarachnoid hemorrhage (SAH). The goal is to better understand which patients might be at higher risk for this condition, so doctors can provide more effective care.

To join this study, participants must be adults who have been admitted to the neurosurgery department with a confirmed case of subarachnoid hemorrhage that falls within certain criteria. Specifically, they should have a modified Fisher scale score of 3-4, which indicates the severity of the bleeding. However, those with certain other conditions—like previous brain injuries, serious medical issues, or specific findings on medical imaging—will not be eligible. For those who qualify, participating in the trial will involve providing samples of cerebrospinal fluid and undergoing regular monitoring as researchers gather important information about their health outcomes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Subarachnoid hemorrhage patients admitted to our neurosurgery department with modified Fisher Scale 3-4, with a confirmed radiographic diagnosis.
• Exclusion Criteria:
• • Angiogram-negative patients, patients with a history of trauma or previous brain injury (stroke, hemorrhage, surgery et al. which left associated chronic changes on CT), arteriovenous malformation, radiological data lost, accompany with serious comorbidities before subarachnoid hemorrhage onset (such as coagulation defects, uncontrollable hypertension, and arrhythmia et.al.), initial radiological data performed more than 3 days after SAH onset