Periodontitis and Inflammation: Study on Biological Samples

Launched by ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS · Aug 21, 2023

Keywords

ClinConnect Summary

This clinical trial is investigating a common gum disease called periodontitis, which affects many adults and can lead to serious health issues. The researchers want to understand how certain immune cells, known as neutrophils, behave in the mouth during different stages of gum health and disease. They believe that these neutrophils might play different roles in how gum disease develops, especially in the transition from gingivitis (a milder form of gum disease) to periodontitis. By studying samples from patients, the team hopes to identify specific neutrophil types and their interactions with bacteria and tissue in the mouth.

To participate in the study, you need to be over 18 years old, speak and understand French, and be willing to take part. The study is looking for individuals with healthy gums, gingivitis, or periodontitis but not those who have recently taken antibiotics or anti-inflammatory medications, are pregnant or breastfeeding, or have certain health conditions affecting neutrophils. If you join, you'll help researchers learn more about this important health issue, which could lead to better ways to identify and treat gum disease in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Common criteria for all patient groups
• • Patient \> 18 years old
• • Patient affiliated to a national health insurance
• • Patient who speaks and understands French well enough to be able to read and understand the study information note.
• • Patient who does not object to his participation in the study
• Specific Criteria :
• • Control Group = BOP \< 10%, PI\<20%, PD≤ 3mm
• • Gingivitis cases = BOP ≥ 10%, PD≤ 3mm
• • Periodontitis cases = BOP ≥ 10%, PD\> 3mm
• Exclusion Criteria:
• • Patients who have received antibiotic prophylaxis, antibiotic therapy, or anti-inflammatory treatment within 3 months prior to inclusion
• • Pregnant or breastfeeding women
• • Patients suffering from a disease with defective neutrophil number, activity, activation or function
• • Patient deprived of liberty by judicial or administrative decision.