Effectiveness of Ketogenic Diet in MELAS Syndrome

Launched by SECOND AFFILIATED HOSPITAL, SCHOOL OF MEDICINE, ZHEJIANG UNIVERSITY · Aug 25, 2023

Keywords

ClinConnect Summary

This clinical trial is exploring how effective a ketogenic diet can be for patients with MELAS syndrome, a rare genetic condition that affects energy production in cells. The trial aims to find out if this special diet can help improve symptoms, prevent the condition from getting worse, and enhance the overall quality of life for those living with MELAS. Researchers will gather information from participants at various points—after 1 month, 3 months, 6 months, and 12 months of following the ketogenic diet—to see how it impacts their health.

To be eligible for this trial, patients must have a confirmed diagnosis of MELAS syndrome and have already tried standard treatments without satisfactory results. They should also be willing to follow the ketogenic diet, which is low in carbohydrates and high in fats. However, certain health conditions, like severe infections or issues with the liver and kidneys, may exclude someone from participating. The trial is not yet recruiting participants, but it promises to provide valuable insights into the potential benefits of the ketogenic diet for those affected by MELAS syndrome.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients who meet the diagnostic criteria of MELAS and have received MELAS standard therapy but are not satisfied with the therapeutic effect, and voluntarily underwent ketogenic therapy
• Exclusion Criteria:
• • Diseases with porphyria and disturbances in fatty acid transport and oxidation, severe electrolyte metabolism abnormalities, severe hemodynamic instability, acute respiratory infections, uncontrolled systemic infections, severe liver and renal failure, cholesterolemia (\>300mgdl), abnormal coagulation, acute pancreatitis, eating disorders, ketogenic diet intolerance, significant weight loss, poor compliance