AST Combined With 0.05% Cyclosporin Eye Drop Improve Corneal Nerve Density in Patients With SS Dry Eye

Launched by CHENGDU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE · Aug 25, 2023

Keywords

ClinConnect Summary

Objective: To describe the clinical efficacy and safety of the treatment of Sjögren's syndrome dry eye using autologous serum tears combined with 0.05% cyclosporin eye drop and to evaluate their effect on corneal nerves.

Design: Singal-center, prospective, observational study. Patients and methods: Thirty eyes of fifteen patients with dry eye related to Sjögren syndrome were enrolled in this study. Following a 4-week washout period, the treatment was inverted for each patient for the same duration and treatment. Ocular Surface Disease Index (OSDI), tear film, break-up time, corneal stainin...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients were diagnosed with SS according to the classification criteria defined by the American-European Consensus Group for the diagnosis of SS and also diagnosed with severe DED based on the consensus of Chinese dry eye experts.
• • Age 18-65 years old.
• • Controlled collagen disease by the same rheumatologists at least 3 months prior to the initiation of the trial.
• • At least one eye that failed to respond to previous treatments including lartificial tears, topical ocular NSAIDs or corticosteroids.
• Exclusion Criteria:
• • Patients with DED related to meibomian gland dysfunction, blepharitis, abnormal blinking, conjunctival relaxation or any other diseases besides SS.
• • Diagnosed with allergic conjunctivitis, uveitis, ocular hypertension, retinopathy and other eye diseases.
• • Those who have a history of previous ocular oprations, eye injuries or contact lenses usage.
• • Known hypersensitivity to experimental drugs or any of its ingredients.
• • Necessity to modify the systemic treatment of previous diseases during the trial.
• • Pregnancy or lactation.
• • Severe systemic disease.