Randomized Controlled Study of Programmed Weaning From NIV for AECOPD

Launched by PEKING UNIVERSITY THIRD HOSPITAL · Aug 25, 2023

Keywords

ClinConnect Summary

This clinical trial is exploring a new way to help patients with acute exacerbations of chronic obstructive pulmonary disease (COPD) gradually stop using noninvasive mechanical ventilation. Noninvasive ventilation is a method that helps patients breathe without needing a breathing tube. The goal of the study is to find a safe process for reducing the time patients spend on this type of support, which could improve their recovery and comfort.

To participate in this trial, individuals must be at least 40 years old and have been diagnosed with an acute worsening of COPD. They should have a specific type of breathing problem that is manageable with noninvasive mechanical ventilation. Unfortunately, individuals who are pregnant, have certain health issues, or are under 40 years old cannot join. Participants can expect to receive careful monitoring and support throughout the trial, and their experiences will help researchers understand the best ways to manage breathing difficulties in COPD patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • It is defined that in patients with acute exacerbation of chronic obstructive pulmonary disease, the arterial blood gas analysis was decompensation of respiratory acidosis, and the pH value was 7.20-7.35
• • Non-invasive mechanical ventilation was performed and it was well tolerated
• Exclusion Criteria:
• • younger than 40 years old
• • pregnancy
• • Human immunodeficiency virus (HIV) antibody was positive
• • Hemodynamic instability
• • Mechanical ventilation for endotracheal intubation and cardiopulmonary resuscitation were disagreed