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Search / Trial NCT06015776

Purinergic Signaling and the Postmenopausal Heart

Launched by BETH ISRAEL DEACONESS MEDICAL CENTER · Aug 28, 2023

Trial Information

Current as of July 22, 2025

Recruiting

Keywords

ClinConnect Summary

This clinical trial, titled "Purinergic Signaling and the Postmenopausal Heart," is studying how changes in hormone levels after menopause may affect the heart, specifically looking at a type of heart failure known as diastolic heart failure. This condition is more common in postmenopausal women, and researchers believe that a decrease in the hormone estrogen may disrupt important processes in the heart, leading to this increased risk. By examining heart tissue from patients undergoing heart surgery, the team hopes to better understand how these changes occur and how they might be linked to heart health.

To participate in this study, individuals must be undergoing heart surgery that requires cardiopulmonary bypass, which is a technique that takes over the function of the heart and lungs during surgery. Some people will not be eligible, including those who have had certain heart conditions or are on hormone replacement therapy. If you or someone you know is interested in joining, the trial is currently recruiting participants of all genders. Those involved can expect to contribute to important research that could help improve understanding and treatment of heart issues in postmenopausal women.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Patients undergoing cardiac surgery under cardiopulmonary bypass.
  • Exclusion Criteria:
  • Refusal to participate
  • Emergency surgery
  • Pre-existing heart block
  • Preexisting atrial fibrillation
  • Redo surgery
  • Estrogen or hormone replacement therapy
  • History of chronic heart failure
  • History of major kidney disease

About Beth Israel Deaconess Medical Center

Beth Israel Deaconess Medical Center (BIDMC) is a leading academic medical center located in Boston, Massachusetts, affiliated with Harvard Medical School. Renowned for its commitment to cutting-edge research and innovation in healthcare, BIDMC fosters a collaborative environment that integrates patient care, education, and scientific investigation. The center actively sponsors clinical trials across a variety of disciplines, aiming to advance medical knowledge and improve patient outcomes. With a focus on translational medicine, BIDMC's research initiatives engage multidisciplinary teams to address complex health challenges and translate findings into effective therapeutic strategies.

Locations

Boston, Massachusetts, United States

Boston, Massachusetts, United States

Patients applied

0 patients applied

Trial Officials

Robina Matyal, MD

Principal Investigator

Beth Israel Deaconess Medical Center, Professor of Anesthesia

Simon Robson, MD, PhD

Principal Investigator

Beth Israel Deaconess Medical Center,Vice Chair Research

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported