Prophylaxis Against Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy

Launched by TANTA UNIVERSITY · Aug 26, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how well different medications can prevent nausea and vomiting after laparoscopic cholecystectomy, which is a surgery to remove the gallbladder. The researchers want to compare two groups: one group will receive dexmedetomidine and ondansetron, while the other group will receive dexamethasone and ondansetron. The main goal is to see how often patients experience nausea and vomiting after their surgery, but they will also look at how severe the nausea is, how often additional medication is needed, and the levels of pain and sedation following the procedure.

To participate in this study, you must be a female patient between the ages of 18 and 65 who is scheduled for elective laparoscopic cholecystectomy and in good health (ASA I or II, which means low risk for surgery). Unfortunately, those over 65 years old, under 18, or with certain health conditions like obesity or liver issues cannot take part. If you join the trial, you can expect to receive one of the two treatment options to help manage potential nausea during your recovery. This study is currently looking for participants, and your involvement could help improve care for future patients undergoing similar surgeries.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 70 Female patients aged between 18 and 65 years
• • ASA I or II
• • patients scheduled for elective laparoscopic cholecystectomy surgery will be included in this study.
• Exclusion Criteria:
• • Females above 65 years old.
• • patients under 18 years old.
• • ASA \> II.
• • Obesity (BMI\>40 kgm2).
• • Known hypersensitivity to drugs used in the study protocol.
• • Comorbidities that were known to increase the risk of PONV (e.g. vestibular disease).
• • Liver or renal dysfunction (liver enzyme or creatinine 1.5 times higher than normal).
• • Alcoholism or drug abuse.
• • Use of antiemetics and psychotropic drugs or glucocorticoids within 24 h before surgery.