The Role of Imaging in the Diagnosis, Management and Prognosis of Possible Non-convulsive Status Epilepticus

Launched by UNIVERSITAIRE ZIEKENHUIZEN KU LEUVEN · Aug 24, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a condition called non-convulsive status epilepticus (NCSE), which is a type of prolonged seizure that doesn't cause the usual shaking or convulsions. Researchers want to find out which brain imaging tests—like PET scans and special MRIs—are best at detecting changes in brain activity that suggest NCSE is present. They will look at both patients showing signs of this condition and healthy volunteers to better understand how these imaging techniques can help diagnose and manage NCSE.

To participate in this trial, individuals should have possible NCSE and show specific patterns on an EEG test, which measures electrical activity in the brain. However, people who cannot undergo MRI scans due to metal implants, have allergies to contrast dyes, or experience severe claustrophobia will not be eligible. Participants will undergo several imaging tests and will be monitored for their response to treatment with seizure medications. The goal is to develop clear guidelines for using imaging tests in diagnosing and managing NCSE, ultimately improving care for patients with this condition.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • - The patient has possible non-convulsive status epilepticus with scalp or invasive EEG with ictal-interictal continuum patterns on EEG
• Exclusion Criteria:
• • The patient has a contra-indication for MRI such as metal implants
• • The patient has contrast sensitivity
• • The patiensuffers from claustrophobia or cannot tolerate confinement during PET-MRI scanning procedures