Chemerin in Colorectal Cancer and Its Relationship With Diet Quality

Launched by HACETTEPE UNIVERSITY · Aug 25, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how a substance called chemerin in the blood relates to inflammation and diet in people with colorectal cancer. Researchers want to understand if levels of chemerin, along with other markers like C-reactive protein and albumin, can tell us something about a person’s diet and overall health. The study will compare these relationships in people with colorectal cancer who have recently had surgery to those who are healthy and have no chronic diseases, focusing on how their eating habits might affect inflammation in the body.

To participate, individuals with colorectal cancer must be between the ages of 18 and 65, have had surgery at least three weeks prior, and cannot be in advanced stages of cancer (Stage IV). Healthy participants must also be in that age range and free from chronic illnesses. Participants will be asked to keep track of what they eat over a day and answer questions about their eating habits. This trial is currently recruiting, and it's important to know that certain health conditions and medication use may exclude someone from participating.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • For patient group
• • Between the ages of 18-65,
• • At least 3 weeks after surgery
• • Individuals newly diagnosed with colorectal cancer by a oncolog (except for Stage IV)
• • For healthy group
• • Between the ages of 18-65,
• • Healthy adult individuals without any chronic disease
• Exclusion Criteria:
• • For patient group
• • Receiving active radiotherapy or chemotherapy,
• • Existing history of metastasis,
• • Having a malignant disease other than the diagnosis of colorectal cancer, - History of metabolic syndrome, cardiovascular disease, hepatic disease, chronic kidney disease, major hormonal or hematological disease, pulmonary disease,
• • With a history of autoimmune disease, with a history of inflammatory diseases (pancreatitis, chron's, ulcerative colitis, etc.),
• • Those who use nonsteroidal anti-inflammatory drugs (NSAIDs),
• • Alcoholic and other drug addicts,
• • Smokers,
• • Those with mental disorders (major depressive disorder, dementia),
• • Those who take corticosteroid or hormone therapy,
• • Those who have an existing infectious disease, those who receive medical nutrition therapy for any disease
• • For healthy group
• • Individuals aged 18 and under and 65 years and older,
• • History of metabolic syndrome, cardiovascular disease, hepatic disease, chronic kidney disease, major hormonal or hematological disease, pulmonary disease,
• • With a history of autoimmune disease, with a history of inflammatory diseases (pancreatitis, chron's, ulcerative colitis, etc.),
• • Those who use nonsteroidal anti-inflammatory drugs (NSAIDs),
• • Pregnant and lactating women,
• • Alcoholic and other drug addicts,
• • Smokers, those with mental disorders (major depressive disorder, dementia),
• • Those taking corticosteroid or hormone therapy,
• • Those with existing infectious disease,
• • Those receiving medical nutrition therapy for any illness