Bioactive Lipids & PBMC

Launched by UNIVERSITÉ CATHOLIQUE DE LOUVAIN · Aug 29, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the effects of certain lipids, which are fats that can influence the body's immune response, on special white blood cells called PBMCs (peripheral blood mononuclear cells) taken from healthy donors. Researchers want to learn how these lipids can affect inflammation by looking at how they change the expression of markers that indicate inflammation in the body. By doing this, they hope to understand the role these lipids play in immune responses better.

To participate in this trial, volunteers must be healthy adults aged 18 and older who can give informed consent and do not have any chronic inflammatory diseases or recent episodes of inflammation, like a cold or flu. If you meet these criteria, you can expect to provide a blood sample from which PBMCs will be isolated and tested with or without the lipids. It's important to note that this trial is not yet recruiting participants, so it will be a while before anyone can join.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Volunteers must be able to give informed consent to be included in the study.
• • no chronic inflammatory disease
• • no acute inflammation
• Exclusion Criteria:
• • Men and women aged less than 18 years
• • Pregnant women
• • Prior diagnosis of a chronic inflammatory disease (for instance IBD, COPD, lupus, MS, etc. This is not an exhaustive list).
• • Recent (\<21 days) episode of acute inflammation or immune-altering event (e.g. cold, flu, vaccine, ...).
• • Chronic or recent use of drugs interfering with the immune / inflammatory response. Examples include (and are not limited to) NSAIDs, corticosteroids, aspirin, mABs, etc.
• • Unable to give informed consent