Effects of Early and Late Time-restricted Eating on Overweight Adults With Metabolic Syndrome

Launched by FIRST AFFILIATED HOSPITAL XI'AN JIAOTONG UNIVERSITY · Aug 29, 2023

Keywords

ClinConnect Summary

This clinical trial is looking to understand how different eating schedules—specifically early and late time-restricted eating—affect overweight adults who have metabolic syndrome. Metabolic syndrome is a group of conditions that increase the risk of heart disease and diabetes, and it is diagnosed when a person has at least three out of five specific health issues, such as high blood pressure, high blood sugar, and abnormal cholesterol levels. The study is not yet recruiting participants, but when it does, it will be open to adults aged 18 to 65 who have a body mass index (BMI) between 24.0 and 40.0.

If you meet these criteria and are interested in participating, you will be asked to follow a specific eating schedule, either early or late in the day, to see how it influences your health. However, there are certain exclusions, such as if you've had a significant weight change recently, if you're pregnant or breastfeeding, or if you work night shifts. This study aims to provide insights on how meal timing can impact health, especially for those dealing with metabolic syndrome.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age from 18 to 65 years
• • 2. Body mass index (BMI): 24.0-40.0 kg/m2
• 3. Diagnosed with metabolic syndrome (i.e., more than 3 abnormal findings out of 5):
• • 1. Waist circumference ≥ 90 cm (men) or ≥ 80 cm (women).
• • 2. Elevated triglyceride (TG) (use of medications for elevated TG is an alternate indicator) ≥ 150 mg/dL (1.7 mmol/L).
• • 3. Reduced high-density lipoprotein cholesterol (HDL-c) (use of medications for reduced HDL-c is an alternate indicator) \< 40 mg/dL (1.0 mmol/L) in males \< 50 mg/dL (1.3 mmol/L) in females.
• • 4. Elevated blood pressure (use of hypoglycemic medications is an alternate indicator). Systolic blood pressure (SBP) ≥ 130 and/or diastolic blood pressure (DBP) ≥ 85 mmHg.
• • 5. Elevated fasting blood glucose (FBG) (used of hypoglycemic medications is an alternate indicator) ≥ 100 mg/dL (5.6 mmol/L).
• Exclusion Criteria:
• • 1. Unstable weight (change \> 10% current body weight) for 3 months prior to the study
• • 2. Pregnant or breast-feeding
• • 3. Night shift workers
• • 4. History of major diseases or related diseases, such as cancer, inflammatory disease, chronic obstructive pulmonary disease and major adverse cardiovascular event
• • 5. Active viral hepatitis, acquired immune deficiency syndrome, syphilis and other sexually transmitted diseases, tuberculosis and other infectious diseases
• • 6. Being treated with antibiotics or corticosteroids
• • 7. Current participate in other weight-management program, current on a prescribed diet for special disease or current on any drugs that effect appetite
• • 8. The researcher deemed it inappropriate to participate in the experimenter.