Effects of Different Continuous Renal Replacement Therapy Patterns on Ionized Calcium in Patients With Citrate Anticoagulants Using Calcium-containing Replacement Solutions

Launched by FUJIAN PROVINCIAL HOSPITAL · Aug 26, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how different methods of a treatment called continuous renal replacement therapy (CRRT) affect levels of ionized calcium in patients who are receiving citrate anticoagulation. In simple terms, CRRT is a way to help filter waste from the blood when the kidneys are not working properly, and citrate anticoagulation is a method used to prevent blood from clotting during this treatment. The researchers want to see if using one method of CRRT over another changes the levels of ionized calcium in the blood.

To participate in this study, you need to be at least 18 years old, receiving citrate anticoagulation, and able to provide consent or have it provided by a family member. If you join, you'll be randomly placed into one of two groups that use different CRRT methods, and you will switch methods in the following treatment session. During the study, your calcium levels and other important measurements will be taken regularly to see how each method affects your calcium levels over time. It's important to note that certain conditions, like severe liver problems or being pregnant, would make you ineligible to participate. Overall, this study aims to help improve the understanding of how to manage calcium levels in patients receiving this type of kidney treatment.

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Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥ 18 years old;
• • 2. Receiving citrate anticoagulation;
• • 3. Obtain Informed consent from patients or next of kin.
• Exclusion Criteria:
• • 1. Pregnant or lactating women;
• • 2. Allergic to citrate anticoagulants;
• • 3. Severe liver dysfunction (total bilirubin levels exceeding two times the normal range);
• • 4. Hypoxemia (PaO2 \< 60 mmHg);
• • 5. Inadequate tissue perfusion (blood pressure \< 90/60 mmHg despite high doses of vasoactive agents);
• • 6. Hyperlactatemia (lactate\> 4 mmol/L);
• • 7. Hypernatremia;
• • 8. Estimated length of hospital stay \< 48h;
• • 9. Participated in other studies.