Koebner's Phenomenon in Psoriasis and Lichen Planus

Launched by MARIE-CHARLOTTE BRÜGGEN · Aug 25, 2023

Keywords

ClinConnect Summary

This clinical trial is exploring a phenomenon known as Koebner's phenomenon, which occurs when skin conditions like psoriasis and lichen planus appear at sites where the skin has been irritated, such as from tight clothing. The researchers want to understand how this irritation triggers inflammation in the skin. To do this, they will gently irritate a small, easily hidden area of skin using methods like tearing off scotch tape or rubbing with a wooden spatula. They will take small skin samples and swabs from the irritated area at the start of the study, and again after three and fourteen days, to examine the skin's response.

To participate, individuals must be diagnosed with psoriasis or lichen planus by a dermatologist, or they can be healthy individuals with no skin conditions. Participants need to be able to give their consent and must not have used specific medications or treatments recently that could interfere with the study. This trial is currently not recruiting participants, but if you or someone you know is interested, it's important to know that this study is focused on understanding skin reactions to irritation, which could help improve treatments for these conditions in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Dermatologist diagnosed psoriasis (group psoriasis), lichen planus (group lichen planus) or no skin disease (group healthy controls)
• • Subject is capable of giving informed consent
• • Signed informed consent
• Exclusion Criteria:
• • Use of systemic immunosuppressive/immunmodulating agents in the last three months
• • Use of topical anti-inflammatory treatment in the last 7 days in the area of sampling.
• • Phototherapy in the last 4 weeks
• • Active or recurrent serious bacterial, fungal or viral infection at the time of enrollment by patient history, including patients with Human Immunodeficiency Virus (HIV) infection, Hepatitis B and Hepatitis C infection, active or untreated latent tuberculosis.
• • Female patients of childbearing potential who are pregnant or breast feeding or planning a pregnancy during the duration of the trial and/or not practicing acceptable birth control for the duration of the trial
• • Known or suspected non-compliance, drug or alcohol abuse,
• • Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant,
• • Previous enrolment into the current study,
• • Enrolment of the investigator, his/her family members, employees and other dependent persons.