A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.

Launched by ONCONANO MEDICINE, INC. · Aug 29, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment called ONM-501, which can be given alone or combined with another medication called cemiplimab, for patients with advanced solid tumors and lymphomas, including types like triple-negative breast cancer and various lymphomas. The main goals of the trial are to find out the highest safe dose of ONM-501 and to see how well it works for these patients, especially those whose cancer has not responded to other treatments.

To participate in this trial, individuals must be at least 18 years old and have a specific type of advanced cancer that cannot be surgically removed or is recurring after previous treatments. They should also have at least one tumor that can be injected for the treatment. Patients with certain medical conditions, such as untreated brain metastases or recent major surgeries, may not be eligible. If selected, participants can expect to receive either the ONM-501 treatment alone or in combination with cemiplimab, and the study will closely monitor their health and response to the treatment throughout the process.

Gender

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Eligibility criteria

• Inclusion Criteria:
• • 1. Ability to understand and willingness to sign written informed consent before performance of any study procedures
• • 2. Age ≥ 18 years
• • 3. Participants with solid tumors or lymphomas, confirmed by available histopathology records or current biopsy, that are advanced, nonresectable, or recurrent and progressing since last antitumor therapy, and for which no alternative standard therapy exists.
• • 4. Participants must have a minimum of one injectable and measurable lesion.
• • 5. Participants with prior Hepatitis B or C are eligible if they have adequate liver function
• • 6. Participants with human immunodeficiency virus (HIV) are eligible if on established HAART for a minimum of 4 weeks prior to enrollment, have an HIV viral load \<400 copies/mL, and have CD4+ T-cell (CD4+) counts ≥ 350 cells/uL
• 7. Adequate bone marrow function:
• • 8. Adequate liver function
• • Exclusion Criteria: Patients will be excluded from this study if they meet any of the following criteria (Part 1a and Part 1b).
• • 1. Other malignancy active within the previous 2 years except for basal or squamous cell skin cancer, superficial bladder cancer, or carcinoma in situ of the cervix or breast that has completed curative therapy.
• • 2. Major surgery within 4 weeks before the first dose of study drug.
• • 3. Brain metastases that are untreated or in the posterior fossa or involve the meninges. Participants with stable or previously treated progressing brain metastases (except in the posterior fossa or involving the meninges) may be permitted in a case-by-case basis at the Sponsor's discretion.
• • 4. Prolongation of corrected QT (QTc) interval to \>470 millisecond (ms) for males and females when electrolytes balance is normal.
• • 5. Females who are breastfeeding or pregnant at screening or baseline
• • 6. Females of childbearing potential that refuse to use a highly effective method of contraception.
• • 7. Has uncontrolled or poorly controlled hypertension as defined by a sustained BP \> 9. Has received prior investigational therapy within 5 half-lives of the agent or 4 weeks before the first administration of study drug, whichever is shorter.
• • 8. Has had any major cardiovascular event within 6 months prior to study drug 10. Has known hypersensitivity to any component in the formulation of ONM-501
• • 9. Has an active infection requiring systemic treatment
• • 10. Is participating in another therapeutic clinical trial
• • Additional Exclusion Criteria for ONM-501 in Combination with cemiplimab (Part 1b)
• • 1. Has known hypersensitivity to any component in the formulation of cemiplimab
• • 2. Has any active or recent history of a known or suspected autoimmune disease or recent history of a syndrome that required systemic corticosteroids (\>10 mg daily prednisone equivalent)
• • 3. Has a condition requiring systemic treatment with corticosteroids