Feasibility of Improving Glycemia With Heat Therapy to Prevent AD

Launched by UNIVERSITY OF KANSAS MEDICAL CENTER · Aug 28, 2023

Keywords

ClinConnect Summary

Aim 1. Examine the effects of heat therapy on blood glucose regulation in older adults at risk for AD. The Investigators will determine the ability of 10 weeks of heat therapy (3 days/week) to improve blood glucose regulation in older adults at risk for AD. Our primary outcome measures will be change in glycated hemoglobin (HbA1c), and change in insulin sensitivity index (ISI) assessed pre- vs post-intervention. The Investigators will also perform continuous glucose monitoring for 7 days prior to and following the intervention, as well as monitor dietary patterns during the intervention. Th...

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Eligibility criteria

• Inclusion Criteria:
• • Age 65 and older
• • Stable medication doses (\>1 month)
• • Post-menopausal
• • Clinical Dementia Rating (CDR) of 0
• • History of or current metabolic impairment (i.e. metabolic syndrome, pre-diabetes, Type 2 Diabetes, etc)
• Exclusion Criteria:
• • Excluded from or unable to complete an MRI scan. MRI compatible pacemakers will require cardiologist clearance prior to enrolling.
• • ACSM Risk score stratification of "High" unless cleared by a physician prior to participation.
• • Myocardial infarction or symptoms of coronary artery disease in the last 2 years.
• • History of or current diagnosis of disorders with the potential to impair cognition (i.e. AD, Parkinson's disease, stroke (defined as clinical episode w/ neuroimaging evidence in appropriate area to explain symptoms)).
• • Insulin-dependent (Type 1) Diabetes Mellitus.
• • Clinically significant chronic disease such as cancer, HIV, or acquired immunodeficiency syndrome.
• • Clinically significant depressive symptoms that may impair cognition, use of psychoactive and investigational medications, and significant visual or auditory impairment.
• • Orthopedic complications that would preclude individuals from safely entering a hot tub.
• • Untreated hypothyroidism or diseases associated with heat intolerance (i.e. Graves disease, etc).
• • Contraindication for temperature pill ingestion (i.e. inflammatory bowel disease, diverticulitis or related).