Microfluidic Chip vs Density Gradient Centrifugation on the Euploidy Rate of Pre-implantation Genetic Testing

Launched by PROFESSOR ERNEST HUNG-YU NG · Aug 28, 2023

Keywords

ClinConnect Summary

This clinical trial is studying two different methods for preparing sperm before it is used for fertilization during in vitro fertilization (IVF) procedures. The goal is to see which method, the microfluidic chip or the density gradient centrifugation, results in healthier embryos that have the right number of chromosomes (known as euploid embryos). This is particularly important for women dealing with infertility and specific genetic conditions.

To participate in this trial, women must be under 43 years old and are undergoing preimplantation genetic testing (PGT) for certain genetic diseases or chromosome issues. Participants will be randomly assigned to one of the two sperm preparation methods, and both the women and the medical staff will not know which method is being used, which helps ensure the study is fair and unbiased. Throughout the trial, participants can expect to follow the usual IVF procedures at the clinic. It's important to note that certain conditions, like having untreated fibroids or previous participation in the study, would exclude someone from joining.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Women aged \<43 years at the time of ovarian stimulation for IVF
• • Women undergoing PGT for monogenic diseases, structural rearrangement of chromosomes or aneuploidy
• • Sperm concentration of the raw semen with at least 0.15 million motile sperm per ml or 100 motile sperm per 50 low power field (200x) of observation
• Exclusion Criteria:
• • Use of frozen semen for insemination
• • Use of donor oocytes and spermatozoa
• • Submucosal fibroid or hydrosalpinx shown on pelvic scanning and not surgically treated;
• • Women who had been recruited into this study before and
• • Women joining other randomized trials