A rTMS and Virtual Reality Based Cognitive Rehabilitation Program for MCI

Launched by CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM · Sep 5, 2023

Keywords

ClinConnect Summary

This clinical trial is studying whether a combination of brain stimulation and virtual reality training can help improve thinking skills and mood in older adults with Mild Cognitive Impairment (MCI). The brain stimulation is done using a method called repetitive Transcranial Magnetic Stimulation (rTMS), which safely sends magnetic pulses to the brain. Participants will either receive standard treatment, rTMS alone, or rTMS along with immersive virtual reality cognitive training (iVCT) for a total of ten sessions over two weeks. The trial aims to find out if the combined treatment can lead to better cognitive function, improved mental health, and a better quality of life compared to the other groups.

To be eligible for this trial, participants must be 55 years old or older and have a diagnosis of Mild Cognitive Impairment, scoring 18 or above on a specific cognitive test. Those who join will first undergo tests to evaluate their thinking, emotional, and daily living abilities. After completing the treatment, participants will be tested again two weeks and three months later to see if there are any lasting benefits. It's important to note that certain health conditions or medications may prevent someone from participating, so a thorough screening will be done. Overall, this trial offers a promising opportunity to explore new ways to help older adults with MCI.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • age 55 and over
• • previous diagnosis of Mild Cognitive Impairment
• • Score of 18 or over on the MoCA during pre-screening procedures.
• Exclusion Criteria:
• • below 55 years old
• • Do not pass the TMS Adult Safety Screening
• • Taking medications known to increase risk of seizure
• • Taking ototoxic medications
• • Those with implanted device
• • History of bipolar disorder
• • History of Tourette's syndrome or presence of motor tics
• • History of seizures/ seizures in first degree relatives
• • History of stroke, aneurysm, or cranial neurosurgery
• • Current alcohol related disorder needing medical treatment
• • History of abnormal electroencephalogram (EEG)
• • History of motion sickness, nausea, vomiting, seizures, or migraine
• • Significant balance/gait impairments/history of falls
• • History of hyperacusis or photophobia