Dead Space in Mechanical Ventilation With Constant Expiratory Flow

Launched by UNIVERSITY HOSPITAL, ANTWERP · Sep 5, 2023

Keywords

ClinConnect Summary

This clinical trial is investigating a new way of helping patients breathe during surgery called flow-controlled ventilation (FCV). This method may improve the removal of carbon dioxide from the body compared to traditional mechanical ventilation, which relies on the natural movement of the chest. The trial will specifically look at how FCV affects "dead space ventilation," which refers to parts of the lungs that don’t get enough blood flow and can be less effective at oxygenating the body. Understanding these differences may help improve care for patients undergoing surgery.

To participate in this trial, you need to be an adult between 18 and 70 years old who is scheduled for elective surgery under general anesthesia and will require controlled mechanical ventilation for at least an hour. You should also be lying on your back during the procedure. However, there are some conditions that would exclude you from joining, such as having severe lung disease or certain heart devices. If you decide to participate, you can expect close monitoring and care throughout the surgery, with the aim of improving breathing support during your procedure.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Adults \[18-70\] yrs
• • General anaesthesia for elective surgery
• • Arterial line, central venous line and endotracheal tube as part of standard of care
• • Expected duration of controlled mechanical ventilation ≥ 60 minutes
• • Supine position (0±10°)
• Exclusion Criteria:
• • One lung ventilation
• • Known pregnancy
• • Increased intra-abdominal pressure (pneumoperitoneum or obesity (BMI \> 30kg/m2))
• • COPD GOLD IV or home oxygen dependence
• • Cardiac pacemaker, implantable cardioverter-defibrillator (ICD) or thoracic neurostimulator
• • Skin lesions (e.g. injury, inflammation) at the level where the Electrical Impedance Tomography (EIT) band is to be applied
• • Clinical signs of raised intracranial pressure
• • Potential interference with the surgery due to the setup of the study instruments.
• • Patient refusal to participate