Evaluation of Diaphragmatic Function and Quadriceps Muscle Thickness in Patients Receiving High Protein Nutrition

Launched by ZAGAZIG UNIVERSITY · Sep 2, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how different amounts of protein in nutrition can affect the strength of the diaphragm (the muscle that helps you breathe) and the thickness of the quadriceps (the muscle at the front of your thigh) in patients who are critically ill and may develop weakness while in the ICU. The goal is to see if providing more protein helps these patients recover better.

To participate, patients must be between 18 and 60 years old, expect to be on a ventilator for at least 48 hours, and likely stay in the ICU for four weeks or longer. They should also have a certain level of nutrition risk. However, there are some criteria that would exclude certain patients, such as those with severe liver disease or who are pregnant. This trial is not recruiting participants yet, but it aims to understand how nutrition can support recovery in critically ill patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • • Acceptance of the first-degree relatives.
• • Critically ill patients: patients with a life-threatening condition that requires pharmacological and/or mechanical support of vital organ functions without which death would be imminent.
• • Patients anticipated to be mechanically ventilated for ≥ 48 hours
• • Patients who expected ICU stay ≥ 4 weeks
• • Patients aged between 18 - 60 years of both sexes.
• • Patient nutrition risk screening (NRS 2002) score ≥ 3
• • Patient BMI less than 35
• • No contraindication to early enteral nutrition.
• Exclusion Criteria:
• • • Patient with Trauma to both lower extremities, diaphragm disease (trauma, immobilization....), myopathy, and moderate to severe hepatic insufficiency.
• • Patient receiving steroids.
• • Patient on renal replacement therapy.
• • Prior MV before admission.
• • Pregnant.
• • Patient with neuromuscular disease, spinal cord injury, thoracic deformity, and respiratory restriction.
• • Patients require muscle paralysis on MV.
• • Patients require high dose inotrope or vasopressor.