Blood Flow Regulation and Neuromuscular Function Post-Stroke

Launched by MEDICAL COLLEGE OF WISCONSIN · Sep 6, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how blood flow to the leg muscles of stroke survivors affects their ability to exercise without getting tired. After a stroke, many people find that their muscles get fatigued more quickly, which can make activities like walking harder. The researchers are looking into a method called ischemic conditioning, a safe and non-invasive technique that may help improve blood flow to these muscles and reduce fatigue during exercise.

To participate in this study, individuals need to be between 18 and 85 years old, have had a stroke at least six months ago, and be able to communicate in English. Participants will undergo tests to assess their muscle function and may experience the ischemic conditioning treatment during the study. It's important to note that some health conditions, like severe high blood pressure or recent heart problems, may prevent someone from joining. This trial aims to help improve physical activity and quality of life for stroke survivors by understanding and enhancing muscle performance.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Be between 18-85 years of age
• • Able to give informed consent
• • ≥6 months post diagnosis of unilateral cortical or sub-cortical stroke
• • English speaking
• Exclusion Criteria:
• • History of blood clots in the extremities or any condition in which compression of the thigh or transient ischemia is contraindicated (e.g. wounds in the leg)
• • Chronic pain syndrome
• • Low back or hip pain that interferes with lower extremity motor testing
• • History of head trauma
• • Comorbid neurological disorder
• • Peripheral vascular disease
• • Myocardial infarction in the previous year
• • Inability to follow 2 step commands
• • Condition where fatiguing contractions or resisted leg contractions are contraindicated
• • Resting SBP ≥160 mmHg or DBP ≥ 110 mmHg
• • Pregnancy or breastfeeding.