Investigation of in Vivo Endogenous and/or Exogenous Production of Phenolic Metabolites Using (un)Targeted Metabolomics

Launched by UNIVERSITY OF PARMA · Aug 31, 2023

Keywords

ClinConnect Summary

This clinical trial is investigating how our bodies process certain plant substances called (poly)phenols, which are found in foods like fruits and vegetables. These substances may have health benefits, especially in preventing diseases. The study will involve 30 healthy adults aged 20 to 40 who regularly drink coffee. Participants will follow a special diet that limits (poly)phenols and will be placed into two groups. One group will drink coffee, while the other will drink water for a few days, and then they will switch drinks after a short break. During the study, researchers will collect urine, feces, and saliva to see how these substances are broken down and what smaller molecules are produced when (poly)phenols are consumed versus when they are not.

To be eligible for this trial, participants should be healthy adults aged 20 to 40 with a body mass index (BMI) between 18 and 28, and they should drink at least one cup of coffee a day. Those with certain health conditions, such as metabolic or cardiovascular diseases, or who are pregnant or breastfeeding, cannot participate. This research aims to help us understand the importance of (poly)phenols in our diet and how our bodies metabolize them, which could lead to better health recommendations in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Apparently healthy adults,
• • Age 20-40 years old,
• • Body mass index (BMI) between 18-28,
• • Regular coffee consumers (at least 1 cup a day).
• Exclusion Criteria:
• • Clinical diagnosis of metabolic diseases,
• • Clinical diagnosis of cardiovascular diseases,
• • Clinical diagnosis of renal diseases,
• • Clinical diagnosis of digestive diseases,
• • Immunodeficiency
• • Autoimmune diseases (other than well-compensated hypothyroidism),
• • Mental disorders
• • Regular use of medication (except birth-control pills and hormone replacement therapies),
• • Use of antibiotics in the last month prior to enrollment,
• • Food allergies or intolerances,
• • Pregnancy
• • Lactation