WMT for Autism Spectrum Disorder (ASD)

Launched by THE SECOND HOSPITAL OF NANJING MEDICAL UNIVERSITY · Sep 7, 2023

Keywords

ClinConnect Summary

This clinical trial, titled "WMT for Autism Spectrum Disorder (ASD)," is investigating a treatment called Washed Microbiota Transplantation (WMT) to see if it can help improve symptoms in children with autism. Researchers believe that the bacteria in our intestines may affect how the brain works, and they want to explore how changing these gut microbes could impact children diagnosed with autism. The trial is currently looking for participants aged 3 to 14 who have been diagnosed with autism for at least three months.

To be eligible for the study, children must meet specific criteria, such as having a diagnosis of autism according to accepted guidelines. However, children with certain medical conditions, like severe gastrointestinal diseases or other serious health issues, cannot participate. Families who join the trial can expect to receive the WMT treatment and help researchers learn more about autism and how it might be treated in the future. It's important to note that this is an early-phase trial, meaning it's one of the first steps in testing this new treatment.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Children who meet Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnostic criteria for at least 3 months.
• • Age 3-17 years.
• • Received WMT
• Exclusion Criteria:
• • their guardian could not understand the questionnaires or provide informed consent.
• • diagnosed with a single-gene disorder, major brain malformations, gastrointestinal diseases (ulcerative colitis, Crohn's disease, or eosinophilic esophagitis)
• • had severe comorbidities including cardiopulmonary failure, severe liver, and kidney diseases, severe infection, tumors, etc.
• • accompanied with other life-threatening disorders required emergency treatment.
• • used antibiotics or probiotics three months before WMT.