Revascularization Effect on CSVD Burden in Carotid Artery Stenosis

Launched by ZHEJIANG PROVINCIAL PEOPLE'S HOSPITAL · Sep 4, 2023

Keywords

ClinConnect Summary

The RECAS trial is studying how a specific treatment called revascularization might help patients with carotid artery stenosis (CAS) and reduce the impact of cerebral small vessel disease (CSVD). In simple terms, CAS is when the arteries in your neck become narrowed, which can affect blood flow to your brain. The trial will compare patients who receive this treatment to those who only take medication. Researchers want to see if revascularization not only slows down the progression of CSVD but also improves eye health and memory.

To participate in this study, you need to be at least 40 years old and have a significant narrowing (more than 50%) in one of your carotid arteries. The study is currently looking for patients and will involve several tests, including brain scans and memory assessments, over a period of up to 10 years. It’s important to know that some individuals, such as those with certain previous medical conditions or severe communication issues, won't be eligible. This study aims to gather valuable information that could help improve treatment options for people with these conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients aged ≥ 40 years.
• • 2. ≥ 50% stenosis in unilateral carotid artery.
• • 3. Sign informed consent.
• Exclusion Criteria:
• • 1. Previous history of major head trauma and any intracranial surgery
• • 2. Intracranial abnormalities, such as intracerebral hemorrhage, subarachnoid hemorrhage, and other space occupying lesions
• • 3. Extrapyramidal symptoms or mental illness which may affect neuropsychological measurement.
• • 4. Severe loss of vision, hearing, or communicative ability.