Integrative Molecular Analysis of Individual Radiosensitivity in Pediatric Oncology

Launched by NEOLYS · Sep 8, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how sensitive children with cancer are to radiation treatment. This is important because some children may react differently to radiation therapy, which is often used to treat various types of tumors. The goal is to understand individual responses to radiation so that doctors can provide safer and more effective treatments for pediatric cancers.

To participate in this study, children and teenagers aged 3 to 17 who are being treated for specific types of cancer, such as brain tumors or Hodgkin's lymphoma, and are scheduled to receive radiation therapy may be eligible. Participants will need to have permission from a parent or guardian and be able to provide a blood sample. Throughout the trial, families can expect support and guidance from the research team, and the information gathered will help improve treatment plans for future patients. It’s also important to note that the study is focused on patients who have not had radiation therapy in the same area before and who do not have any serious reasons that would prevent them from participating.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Minor patient treated for a brain tumor, Ewing tumor, malignant mesenchymal tumor, neuroblastoma, nephroblastoma, Hodgkin's lymphoma treated with radiotherapy (+/- chemotherapy) for curative purposes.
• • Children or adolescents \> 3 years old and \< 18 years old
• • Patient with an indication for radiotherapy as part of the primary tumor local control strategy
• • Theoretical indication for radiotherapy in standard fractionation (1.8 Gy to 2.2 Gy / fraction: 5 fr/week) whatever the technique and the particle used
• • Patient affiliated with a social security scheme
• • Patient and/or parents or holders of parental authority having dated and signed an informed consent
• Exclusion criteria:
• • Patients with contraindications to blood sampling
• • Patients with contraindications to radiotherapy
• • Palliative radiotherapy
• • Patient with previous RT treatment in the same area (re-irradiation)
• • Patient with an indication of hypofractionated RT
• • Patient follow-up not possible
• • Persons deprived of liberty or under guardianship (including curatorship)
• Exclusion Criteria:
• • -