Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis

Launched by COLUMBIA UNIVERSITY · Sep 5, 2023

Keywords

ClinConnect Summary

This clinical trial is investigating how to identify early signs of a condition called transthyretin cardiac amyloidosis (ATTR-CA) in older adults who have had surgery for lumbar spinal stenosis (LSS), which is a narrowing of the spine that can cause pain and mobility issues. The goal is to find patients who may have amyloid deposits in their spinal tissue, as these deposits could indicate a risk for developing heart problems related to ATTR-CA. By identifying these patients early, doctors can start treatment when it may be most effective.

To be eligible for this study, participants must be at least 50 years old and have had spinal surgery within the last 20 years. It's important that they can understand the study's purpose and agree to participate. Participants will undergo tests to check for amyloid deposits in their spinal tissue and may also use new technology to help identify these deposits. Overall, the trial aims to better understand how common ATTR-CA is in this group and to improve early detection methods, which could lead to better treatment options in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Clinically indicated spinal decompressive surgery within 20 years prior to enrollment.
• • 2. Age ≥50 years at the time of the surgery.
• • 3. Able to understand and sign the informed consent document after the nature of the study has been fully explained.
• Exclusion Criteria:
• The presence of any of the following excludes eligibility for enrollment in this study:
• • 1. Confirmed primary amyloidosis (AL) or secondary amyloidosis (AA).
• • 2. Known TTR amyloidosis.
• • 3. Other reason that would make the subject inappropriate for entry into this study.