Intestinal Flora and Metabonomics of Appendicitis

Launched by HONGYIQU · Sep 5, 2023

Keywords

ClinConnect Summary

This clinical trial is focused on understanding the types of bacteria and metabolites (small molecules produced by metabolism) in the intestines of children with appendicitis. Researchers want to find out what specific bacteria and substances are linked to appendicitis in young patients. They will compare samples from children diagnosed with appendicitis to those from healthy children to identify key differences. This study is important because it may help doctors in the future to better diagnose and treat appendicitis in children.

To participate, children aged 1 to 14 who have been diagnosed with appendicitis and have undergone a specific surgery called laparoscopic appendectomy are eligible. Children without digestive tract diseases and a history of such issues may also be included. However, children with certain conditions, such as a family history of intestinal diseases or those taking specific long-term medications, cannot take part in the trial. Participants will provide stool samples, which will be analyzed to uncover important information about their intestinal bacteria and metabolites. This research could lead to better understanding and treatment options for appendicitis.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Children aged 1-14 years who were initially diagnosed with appendicitis and underwent laparoscopic appendectomy
• • Children aged 1-14 years with non-digestive tract disease and no history of digestive tract disease
• Exclusion Criteria:
• • A family history of intestinal disease
• • Allergic to antibiotic therapy drugs
• • Patients with long-term drug use causing microbial structure changes or intestinal flora disorders
• • Patients with other congenital diseases such as Meckel's diverticulum, intestinal rotation and other malrotation
• • With other systemic diseases, such as obvious upper respiratory tract infection or myocarditis
• • Children with other digestive system diseases after auxiliary examination or surgical diagnosis