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Search / Trial NCT06035185

Microbial Load After Apical Enlargement in Asymptomatic Teeth With Periapical Lesion

Launched by ISTANBUL MEDIPOL UNIVERSITY HOSPITAL · Sep 6, 2023

Trial Information

Current as of June 26, 2025

Not yet recruiting

Keywords

Apical Shaping Droplet Digital Pcr Irrigation Activation Microbial Load Root Canal Cleanliness

ClinConnect Summary

This clinical trial is studying how different techniques used during root canal treatments can affect the cleanliness of the tooth. Specifically, it aims to find out if the way the dentist shapes the tooth’s root and how they clean it with fluids makes a difference in reducing infection in teeth that have a problem at the tip of the root, known as a periapical lesion. The researchers want to answer whether using more aggressive cleaning methods is necessary when the root is shaped more carefully, or if just shaping the root well is enough to keep the tooth clean.

To participate in this study, you need to be between 18 and 65 years old and have molar teeth with specific issues visible on dental X-rays. You should also be in good health according to a standard classification used by anesthesiologists. If you join the study, you will be asked to sign a consent form, and you should be able to tolerate the treatment both physically and mentally. The trial is not yet recruiting participants, so if you're interested, it’s important to stay updated on when they will start.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Patients between the ages of 18-65
  • Patients complying with the ASA1 and ASA2 classification (American Society of Anesthesiology)
  • Patients who has molar teeth with radiolucent lesions in the periapical region
  • The volunteer himself/herself or his/her legal representative wants to participate in the research by signing the 'Voluntary Consent Form'.
  • Being able to tolerate the treatment physically and mentally
  • Exclusion Criteria:
  • Patients who have taken antibiotics/corticosteroids in the last 3 months
  • Patients with systemic disease
  • Teeth that cannot be properly isolated with a rubber dam
  • Teeth without coronal sealing,
  • Teeth with periodontal pocket depth\>4 mm and teeth with crown / root fracture.
  • Individuals who continue or are considering starting orthodontic treatment during the research
  • Pregnant and lactating individuals
  • The volunteer himself/herself or his/her legal representative does not want to participate in the research by signing the 'Voluntary Consent Form'.
  • Teeth that are damaged enough to require post-core treatment.

About Istanbul Medipol University Hospital

Istanbul Medipol University Hospital is a leading healthcare institution in Turkey, renowned for its commitment to advanced medical research and clinical excellence. As a prominent sponsor of clinical trials, the hospital leverages its state-of-the-art facilities and a multidisciplinary team of experts to facilitate innovative studies across various medical fields. With a strong emphasis on patient safety and ethical standards, Istanbul Medipol University Hospital strives to contribute to the advancement of medical knowledge and the development of effective treatments, ensuring high-quality care and improved health outcomes for patients.

Locations

Istanbul, , Turkey

Patients applied

0 patients applied

Trial Officials

Tan Firat Eyüboglu, PhD, JSD

Principal Investigator

Istanbul Medipol University Hospital

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported