LATe Cerclage in High-risk Pregnancies (LATCH)

Launched by THOMAS JEFFERSON UNIVERSITY · Sep 11, 2023

Keywords

ClinConnect Summary

The LATe Cerclage in High-risk Pregnancies (LATCH) clinical trial is studying whether a procedure called cervical cerclage can help prevent premature birth in certain pregnant women. Cervical cerclage involves placing a stitch around the cervix to help support it if it is shorter than normal, which can increase the risk of early delivery. This trial is focused on women who are between 24 and 26 weeks pregnant with a cervical length of 25 millimeters or less.

To be eligible for this trial, participants must be between 18 and 50 years old, pregnant with one baby, and have the specific cervical measurement mentioned. Unfortunately, not everyone can participate. For example, women with certain complications, like active bleeding or infections, or those already receiving similar treatments, cannot join. If someone decides to participate, they will receive close monitoring and care throughout the trial. This research hopes to provide important information that could help improve outcomes for women at risk of premature birth.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 18-50 years old, pregnant, assigned female at birth
• • Singleton pregnancy
• • TVU CL ≤25mm between 24 0/7 - 26 6/7 weeks of gestation
• Exclusion Criteria:
• • Initial multifetal gestation with subsequent multifetal pregnancy reduction, or selective fetal termination performed \>14 weeks, or cotwin pregnancy loss diagnosed \>14 weeks
• • Cerclage in situ
• • Preterm labor, defined as painful regular uterine contractions and change in cervical dilation
• • PPROM
• • Active vaginal bleeding
• • Suspected intraamniotic infection
• • Major fetal structural abnormality or chromosomal disorder
• • Placenta previa or accreta
• • Other contraindication to cerclage placement
• • Participation in another clinical trial related to preterm birth prevention, cerclage, or progesterone