Urin-based Point-of-Care Testing for Direct Oral Anticoagulants in Stroke Patients

Launched by UNIVERSITY OF GIESSEN · Sep 13, 2023

Keywords

ClinConnect Summary

This clinical trial is studying a new urine test designed to quickly identify if stroke patients have taken certain blood-thinning medications known as direct oral anticoagulants (DOACs). The main goals are to see if this urine test can effectively detect these medications, whether it provides faster results compared to traditional blood tests, and if it can be easily used in emergency settings for stroke care. The trial is currently looking for participants aged 18 and older who have been diagnosed with either ischemic (caused by a blockage) or hemorrhagic (caused by bleeding) stroke and are being treated at the University Hospital Giessen.

If you or a family member are considering participating, you'll need to have been admitted for a stroke and may need to meet specific criteria related to medication intake. Participants can expect to undergo the urine test as part of their care, and the study will help researchers understand the benefits of using this new testing method in urgent situations. It's important to note that some patients may not be eligible if they have certain medical conditions or if they require specific treatments.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patient age ≥18 years at the time of admission
• • Clinical diagnosis of ischemic or hemorrhagic stroke.
• • Treatmet at our certified stroke-unit, University Hospital Giessen.
• • Phase 1 only: Confirmed intake of a direct oral anticoagulant (DOAC) for at least 48 hours (test group) or no intake of a DOAC (control group for specificity determination)
• • Phase II only, anamnestic intake of DOAC or no information about OAC-intake.
• • Phase II only, presentation with 4.5 hours after onset.
• Exclusion Criteria (only Phase II):
• • Contraindications for intravenous thrombolysis other than intake of DOAC
• • large vessel occlusion with indication for immediate endovascular thrombectomy
• • chronic renal insufficiency with need for hemodialysis