Evaluation of Integrated Versus Parallel Connection for Renal Replacement Therapy in ECMO Patients

Launched by HOSPICES CIVILS DE LYON · Sep 7, 2023

Keywords

ClinConnect Summary

This clinical trial is studying two different ways to provide kidney support (called renal replacement therapy or RRT) for patients who are on a special heart and lung support system known as venoarterial extracorporeal membrane oxygenation (VA-ECMO). Patients on VA-ECMO are at risk of developing kidney problems, and about half of them may need additional kidney support. The trial is comparing two methods: one where the kidney support is given through a separate access point in the bloodstream (parallel connection) and another where it is integrated directly into the VA-ECMO system (integrated connection). The goal is to find out if the integrated method is just as effective in keeping the kidney filter working well without causing extra complications.

To be eligible for this trial, participants must be between 18 and 75 years old, be on VA-ECMO, and need continuous kidney support while staying in the intensive care unit for more than 24 hours. Some individuals, like those who cannot have a new catheter placed or have certain legal or health issues, will not be included. If you join the study, you can expect close monitoring and care to see which method of kidney support works better for your situation. This research could help improve the treatment of patients like you in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients between 18 and 75 years of age
• • Patient on VA-ECMO who requires the initiation of continuous RRT during VA-ECMO treatment
• • Patient with a foreseeable length of stay in intensive care greater than 24 hours
• Exclusion Criteria:
• • Patient who does not have a vascular capital allowing for the insertion of a new dialysis catheter to administer RRT and therefore cannot be randomized to the parallel connection group
• • High pressures monitored on ECMO not allowing direct RRT catherter on ECMO
• • Pregnant, parturient, or breastfeeding women
• • Patient deprived of liberty by a judicial or administrative decision
• • Patient under psychiatric care
• • Patient subject to a legal protection measure (guardianship, curators)
• • Patient not affiliated to a social security system
• • Patient participating in another interventional research study in the field of extra purification renal