NAC Vs Placebo on Opioid Use for Hysterectomy

Launched by MEDICAL UNIVERSITY OF SOUTH CAROLINA · Sep 8, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a medication called N-acetylcysteine (NAC) on pain and the use of opioid medications after a hysterectomy, which is a surgery to remove part or all of a woman's uterus. The trial is looking for women aged 18 and older who are planning to have this surgery using either a laparoscopic (small incision) or robotic technique. Participants will be randomly assigned to receive either NAC or a placebo (a substance with no active medication) during the surgery. After the procedure, the women will be asked about their pain levels and any pain medication they take.

To be eligible for this trial, women must be undergoing an elective hysterectomy and be at least 18 years old. However, there are some exclusions; for example, those who weigh less than 40 kg, have a history of allergic reactions to NAC, or have certain medical conditions like asthma or blood clotting disorders cannot participate. This study aims to help improve pain management after surgery, and participants will have the opportunity to contribute to important research while receiving care related to their surgery.

Gender

ALL

Eligibility criteria

• • Inclusion
• • Undergoing elective laparoscopic or robotic, full, or partial hysterectomy procedure
• • 18 years of age and older
• • Exclusion
• • Less than 40kg in weight
• • Unable to provide written, informed consent
• • History of an adverse or anaphylactoid reaction to acetylcysteine
• • Active asthma, wheezing, or using inhaled bronchodilators
• • Non-English speaking
• • Insulin dependent diabetes if D5W is required
• • Blood clotting disorders