Natural History of Coronary Atherosclerosis

Launched by CHINA NATIONAL CENTER FOR CARDIOVASCULAR DISEASES · Sep 13, 2023

Keywords

ClinConnect Summary

This clinical trial, titled "Natural History of Coronary Atherosclerosis," is investigating how well a measurement called radial wall strain (RWS) can help predict the progression of coronary artery disease compared to another method called optical coherence tomography (OCT). The focus is on understanding how these measurements can indicate changes in the arteries over the course of one year, specifically looking for significant increases in artery narrowing.

If you're considering participating in this study, you need to be at least 18 years old and have had a heart attack within the last 45 days. You should also be scheduled for a coronary angiography, which is a type of imaging test for your heart. However, if you are experiencing severe heart problems, are pregnant, or have a limited life expectancy due to non-heart-related issues, you may not be eligible. Participants will undergo tests to measure their artery conditions and will help researchers gather important information about heart health. This study is currently recruiting participants of all genders.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * General Inclusion Criteria:
• • 1. Age ≥18 years
• • 2. Acute myocardial infarction ≤ 45 days
• • 3. Planned coronary angiography examination or potential interventional treatment
• * Angiographic Inclusion Criteria:
• • 1. The presence of at least 1 non-flow-restricting lesion (visually estimated diameter stenosis: 30%-80%; QFR \> 0.80) in any non-infarct related artery with RVD ≥2.5 mm by visual assessment
• Exclusion Criteria:
• * General exclusion Criteria:
• • 1. Cardiogenic shock
• • 2. Pregnant or woman of child-bearing potential
• • 3. Life expectancy less than 1 year for non-cardiac causes
• • 4. Unable to tolerate contrast agents or anticoagulant/antiplatelet therapy
• • 5. Prior CABG or planned CABG
• * Angiographic exclusion Criteria:
• • 1. Poor angiographic image quality precluding vessel contour detection or with suboptimal contrast opacification, branch ostium cannot be shown clearly, severe overlap in the stenosed segment or severe tortuosity of any interrogated vessel deemed not amenable to QFR or RWS measurement
• • 2. An interrogated lesion require surgical bypass grafting
• • 3. Unable to judge culprit lesion or infarct-related artery according to current evidence