Impact of Pomegranate Seed Oil on Postprandial Cardiovascular Disease Risk Markers

Launched by UNIVERSITY OF READING · Sep 16, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the effects of pomegranate seed oil on heart health markers in postmenopausal women. Researchers want to see if meals containing pomegranate seed oil can improve blood fat levels and other indicators that relate to cardiovascular disease. The trial will involve 15 healthy postmenopausal women, who will be asked to consume two different types of meals on separate occasions—one containing pomegranate seed oil and one as a placebo. The study will measure various health indicators, such as blood pressure and blood samples, to understand how these meals impact heart health.

To be eligible for this trial, participants must be postmenopausal for at least 12 months, aged 65 or younger, and have certain health measurements within specified ranges (like blood fat and glucose levels). Women who smoke, have certain health conditions, or take specific medications that could affect the results are not eligible. Participants can expect to visit the study site twice, with a break of 4-6 weeks between visits, where they will undergo health checks and provide blood samples. This research could provide valuable insights into how dietary choices, like including pomegranate seed oil, might benefit heart health in postmenopausal women.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • Postmenopausal women who have been postmenopausal for at least 12 months.
• • Aged 65 and under years
• • Serum TAG \< 2.3 mmol/l
• • Body mass index (BMI) between 18-35 kg/m2
• • Fasting total cholesterol \< 7.5 mmol/l
• • Fasting glucose concentration \<7 mmol/L
• Exclusion Criteria:
• • Smokers
• • Medical history of myocardial infarction or stroke in the past 12 months
• • Diabetes (defined as fasting glucose \> 7.0 mmol/l) or other endocrine disorders
• • Kidney, liver, pancreas or gastrointestinal disorder
• • Hypertension (blood pressure \> 140/90 mmHg), cancer, medication for hyperlipidaemia (e.g. statins), hypertension or, inflammation
• • Anaemia (\<115 g/L haemoglobin)
• • Taking any dietary supplements known to influence lipids/gut microbiota (e.g. plant stanols, fish oil, phytochemicals, natural laxatives, probiotics and prebiotics)
• • Drinking in excess of 14 units of alcohol per week
• • Planning on a weight-reducing regime
• • Parallel participation in another dietary intervention study
• • Any other unusual medical history or diet and lifestyle habits or practices that would preclude volunteers from participating in a dietary intervention and metabolic study