Barbed Suture vs Non-Barbed Closure for Emergency Exploratory Laparotomy RCT
Launched by UNIVERSITY OF SOUTHERN CALIFORNIA · Sep 12, 2023
Trial Information
Current as of June 26, 2025
Not yet recruiting
Keywords
ClinConnect Summary
This clinical trial is comparing two types of sutures used to close the abdominal wall after emergency surgery, specifically after a procedure called exploratory laparotomy. The study is looking at a special kind of suture called triclosan-coated barbed suture, which is designed to reduce the risk of surgical site infections and wound complications, compared to a traditional non-barbed suture. The goal is to find out which suture helps patients heal better within 30 days after their surgery.
Eligible participants for this study are adults aged 18 and older who need emergency surgery on their abdomen due to injuries or other urgent medical issues. To participate, individuals must have a specific type of surgical wound and must be able to complete the surgery without any major complications. During the trial, participants will receive one of the two types of sutures, and their recovery will be monitored for a month to check for any infections or wound issues. This study will take place at the Los Angeles General Medical Center, and it aims to provide important information that could improve surgical care in the future.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • All adult individuals aged 18 years or older who undergo emergent laparotomy via a midline approach for trauma or non-trauma emergency general surgery who undergo complete fascial closure at the time of the index laparotomy operation.
- • Individuals with CDC Class I, II, III and IV type surgical wounds
- Exclusion Criteria:
- • Individuals under 18 years of age
- • Individuals with known immune deficiencies
- • Individuals taking chronic immunosuppressive medications
- • Individuals presenting with nosocomial infections
- • Individuals presenting with pre-existing abdominal wall hernia
- • Individuals requiring multiple operations for sequential fascial closure
- • Individuals incarcerated at time of operation
- • Individuals with known preexisting connective tissue disease
- • Individuals with known preexisting ventral abdominal wall hernia
- • Individuals who are pregnant time of operation
- • Individuals who are deceased prior to conclusion of exploratory laparotomy
- • Individuals lost to follow-up or deceased during the first 30 days after laparotomy.
About University Of Southern California
The University of Southern California (USC) is a prestigious research institution located in Los Angeles, California, known for its commitment to advancing knowledge and innovation in various fields, including medicine and health sciences. As a clinical trial sponsor, USC leverages its extensive resources, interdisciplinary expertise, and state-of-the-art facilities to conduct cutting-edge research aimed at improving patient outcomes and public health. The university fosters collaboration among its diverse faculty and students, ensuring a dynamic environment for the development and implementation of clinical studies that adhere to the highest ethical and scientific standards. Through its clinical trials, USC aims to contribute to the advancement of medical science and the translation of research findings into practical applications that benefit communities locally and globally.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Los Angeles, California, United States
Patients applied
Trial Officials
Matthew Martin, MD
Principal Investigator
Los Angeles General Medical Center
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported