Effect of Dexamethason on Postimplantation Syndrome After EVAR

Launched by CENTRO HOSPITALAR DE LISBOA CENTRAL · Sep 13, 2023

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a medication called dexamethasone on patients who are undergoing a specific type of surgery called endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms. The trial aims to see if giving patients a single dose of dexamethasone before surgery can help reduce a condition known as postimplantation syndrome, which can cause discomfort and complications after the procedure. Researchers will compare the effects of this medication to standard treatment to find out which is better.

To participate in this trial, you must be an adult aged 65 to 74 who is scheduled for elective surgery to treat a degenerative abdominal aortic aneurysm using an endograft, which is a type of device used to repair the aneurysm. Some additional procedures may be allowed during the surgery. However, individuals with certain conditions, such as infections or known inflammatory diseases, will not be eligible. Participants can expect to receive either dexamethasone or standard treatment before their surgery, and all necessary information about the trial will be provided so they can make an informed decision about joining. The trial is not yet recruiting, but it is following strict ethical guidelines to ensure patient safety and care.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Elective treatment for a degenerative infrarenal abdominal aortic aneurysm by implantation of an endograft
• • Additional procedures, as endoanchors, proximal extension with a cuff or iliac branch device, during primary EVAR are allowed.
• Exclusion criteria:
• • Mycotic aneurysms, aortic dissections and inflammatory aneurysms
• • Known inflammatory or infectious diseases
• • Preoperative anti-inflammatory therapeutic