High- and Low-dose Radiotherapy Combined With PD-1 Inhibitors for MSS CRLM

Launched by JIANGSU CANCER INSTITUTE & HOSPITAL · Sep 13, 2023

Keywords

ClinConnect Summary

This clinical trial is exploring how effective and safe it is to use high- and low-dose radiation therapy along with a type of medication called PD-1 inhibitors for patients with colorectal cancer that has spread to the liver. Specifically, the study focuses on patients whose cancer has not responded to at least two previous treatments. The researchers want to see if this combination can help these patients who have limited treatment options left.

To participate in the trial, patients need to be between 18 and 70 years old, have specific types of colorectal liver metastases, and be in good enough health (with a score of 0 or 1 on a scale that measures health status). Participants must also be willing to avoid other cancer treatments during the study. If you or a loved one is considering this trial, know that it is currently recruiting participants and aims to provide new insights into treatment options for those facing advanced colorectal cancer.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patients with microsatellite stable colorectal liver metastases and failure with second-line or above therapy, and no subsequent standard treatment regimen.
• • 2. Patients with an ECOG score of 0 or 1, and an expected survival period of ≥6 months.
• • 3. During the study, they are willing to follow the arrangement and not use other systemic anti-tumor drugs such as chemotherapy, targeted, Chinese herbal medicine, and proprietary Chinese medicine.
• • 4. 18-70 years old, no gender limit.
• Exclusion Criteria:
• • 1. Those with a history of severe immediate allergy to the drugs used in this study.
• • 2. Cancer patients who require urgent surgical intervention, such as high-risk pathological fractures, life-threatening bleeding symptoms, etc.
• • 3. Any of the following conditions in the 6 months before screening: myocardial infarction, severe/unstable angina, coronary artery/peripheral artery bypass graft, symptomatic congestive heart failure, cerebrovascular accident, transient cerebral ischemia Onset or symptomatic pulmonary embolism. Patients with known coronary artery disease, congestive heart failure that does not meet the above criteria or left ventricular ejection fraction \<50% must adopt an optimized and stable medical plan determined by the treating doctor. If appropriate, you can consult a cardiologist.
• • 4. Patients with active infection requiring systemic treatment.