Screening for Primary Aldosteronism in Hypertension With 24-hour URinary aLdosterone

Launched by DR IAN B WILKINSON · Sep 15, 2023

Keywords

ClinConnect Summary

This clinical trial is studying two different tests to see which one is better at identifying a condition called primary aldosteronism in people with high blood pressure (hypertension). The focus is on patients who are younger and have had high blood pressure start at an early age, specifically between 18 and 60 years. The researchers want to compare the "plasma aldosterone renin ratio" test and a "24-hour urine aldosterone" test to find out how effectively they can detect this condition.

To be eligible for this study, participants need to be at least 18 years old and have high blood pressure that started when they were between 18 and 60 years old. Those suspected of having primary aldosteronism should have high blood pressure that is difficult to treat or have low potassium levels. If you join the study, you can expect to undergo these tests and share your health information with the researchers. It's important to know that certain health conditions or situations, like being pregnant or having severe high blood pressure, may prevent someone from participating in the trial. The study is currently looking for participants, so if you meet the criteria, you may have the opportunity to contribute to important research.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * A patient will be eligible for inclusion in this trial only if all of the following criteria apply:
• • Aged 18 years and above.
• • Meets NICE criteria for a diagnosis of hypertension with an age of onset of hypertension between 18-60 years.
• • For cohort 2 (suspected primary aldosteronism): resistant hypertension, and/or hypertension with spontaneous or diuretic-induced hypokalaemia, and/or hypertension.
• Exclusion Criteria:
• • • Severe hypertension (sustained blood pressure of \>200/110 mmHg) or a history of known secondary hypertension other than PA.
• • Contraindications to confirmatory testing with saline infusion or oral salt loading test as per standard clinical criteria such as known clinical diagnosis of heart failure, and/or chronic kidney disease stage 3b.
• • Known Pregnancy or breast feeding.
• • Lack of informed consent.
• • Any medical condition deemed unsuitable by investigator for participation in the study