TANGO-LIVER Three Arm Nuclear Growth Observation in Liver Surgery

Launched by MEDICAL UNIVERSITY OF WARSAW · Sep 17, 2023

Keywords

ClinConnect Summary

The TANGO-LIVER trial is studying three different methods to help patients with liver cancer or liver metastases prepare for surgery. Sometimes, surgery isn't possible because the remaining healthy part of the liver is too small. This trial compares three techniques to increase the size of the future remnant liver (the part that stays after surgery): Portal Vein Embolization (blocking a vein to redirect blood flow), Liver Vein Deprivation (blocking multiple veins), and a partial version of ALPPS (a more complex procedure that involves partially cutting the liver). The goal is to see which method is the most effective and safe in allowing patients to undergo a successful liver resection, which is the surgical removal of part of the liver.

To be eligible for this trial, participants must be at least 18 years old, be candidates for liver surgery, and have a future remnant liver volume of less than 30% of what is considered normal. During the trial, participants will undergo imaging tests to monitor liver size and function before and after the treatment methods. The study will track complications and how well each method works in preparing patients for surgery. This trial is currently recruiting participants, and all involved will be monitored throughout the process to ensure safety and gather important information about their outcomes.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • age \>= 18 years
• • patients qualified for liver resection
• • future remnant liver \<30% of standard liver volume
• • written informed consent
• Exclusion Criteria:
• • liver cirrhosis
• • pregnancy
• • poor general health status or comorbidities excluding general anesthesia or hepatic resection
• • contraindications to iodine contrast agents