Prognostic Prediction Model in Patients With Moyamoya Disease Undergoing Revascularization Surgery

Launched by BEIJING TIANTAN HOSPITAL · Sep 18, 2023

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ClinConnect Summary

This clinical trial is focused on improving care for patients with Moyamoya Disease (MMD), a rare condition that affects blood flow to the brain and can lead to serious issues like strokes. The researchers aim to create a comprehensive prediction model that helps doctors better understand how patients will respond to a specific surgery called revascularization, which is used to restore blood flow. By collecting detailed information about patients before, during, and after surgery, the study hopes to improve decision-making and outcomes for those undergoing treatment for this condition.

To participate in this trial, individuals must be at least 18 years old and have a confirmed diagnosis of Moyamoya Disease through imaging tests. They should be scheduled for the revascularization surgery and must provide consent to take part. Unfortunately, certain people will not be eligible, such as those with severe heart or lung issues or other health conditions that could complicate their participation. If you or someone you know is considering joining this study, it could be an opportunity to contribute to important research that aims to enhance the understanding and treatment of Moyamoya Disease.

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Eligibility criteria

• Inclusion Criteria:
• • 1. Age greater than or equal to 18 years.
• • 2. Imaging-confirmed moyamoya disease (CTA, CT angiography; MRA, magnetic resonance angiography；DSA, digital subtraction angiography）for MMD patients.
• • 3. Selective Revascularization Surgery (direct or indirect);
• • 4. Signed informed consent by the patient or legal representative.
• Exclusion Criteria:
• • 1. patients with moyamoya syndrome due to an established secondary etiology.
• • 2. with severe cardiopulmonary disease that, in the opinion of the investigator, makes them unsuitable for participation in this study.
• • 3. patients with a life expectancy of less than 3 months or otherwise unable to complete this study.
• • 4. contraindication to DSA examination, severe contrast allergy or absolute contraindication to iodine contrast;
• • 5. women of childbearing age who have a negative pregnancy test but refuse to use effective contraception.
• • 6. women during pregnancy or breastfeeding.
• • 7. those who are unable to complete the study due to psychiatric disorders, cognitive or mood disorders.
• • 8. other patients who, in the opinion of the investigator, are not suitable for enrollment in the study (indicate reason).