Efficacy and Safety of SCRT Versus TNT in Older Patients With Locally Advanced Rectal Cancer

Launched by JULES BORDET INSTITUTE · Sep 18, 2023

Keywords

ClinConnect Summary

The SHAPERS study is a clinical trial designed to find out which treatment is more effective and safe for older patients (70 years and older) with locally advanced rectal cancer. Specifically, it compares two types of pre-surgery treatments: standard care and a newer approach called SCRT. The goal is to see how well these treatments work for patients who are at a higher risk due to the stage of their cancer.

To participate in this study, patients must be at least 70 years old and have a specific type of rectal cancer that is operable. They also need to have good overall health, meaning they can perform daily activities with minimal assistance. Participants will receive either the standard treatment or the new treatment before surgery, and they will be monitored closely throughout the study. This trial is currently recruiting participants, and anyone considering joining should discuss it with their doctor to see if they qualify and to understand what the process will involve.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age ≥ 70 years old
• 2. ECOG performance status (PS):
• • ≤1 if age \> 75 years old
• • ≤2 if age ≤ 75 years old
• • 3. Histologically or cytologically confirmed adenocarcinoma of the rectum
• • 4. Distal border of the tumour below the peritoneal reflection and within 15 cm of the anal verge
• • 5. Operable stage III or high-risk stage II rectal cancer (high-risk tumours defined as those having ≥1 of the following features: T4, mesorectal fascia (MRF) involvement/threatening \[i.e.,tumour within 1 mm of the MRF\], extramural venous invasion). Patient with involvement of lateral pelvic lymph nodes are also eligible.
• 6. Adequate bone marrow function as defined below:
• • Absolute neutrophil count ≥1,500/µL
• • Haemoglobin ≥9 g/dL
• • Platelets ≥100,000/µL
• 7. Adequate liver function as defined below:
• • Serum total bilirubin ≤1.5 x ULN. In case of known Gilbert's syndrome \<3xUNL is allowed
• • AST (SGOT) and ALT (SGPT) ≤2.5 x ULN
• • Alkaline phosphatase ≤2.5 x ULN
• • 8. Adequate renal function as defined by estimated glomerular filtration rate (GFR) ≥30 mL/min/1.73m² (according to the CKD-EPI 2021 equation).
• • 9. Absence of clinical conditions that in the opinion of the investigator, would contraindicate neoadjuvant therapy and/or surgery.
• • 10. Signed Informed Consent form (ICF) obtained prior to any study related procedure.
• • 11. Male subjects with partners of childbearing potential must agree to use condom during the course of this study and for at least 6 months after the last administration of study drugs.
• Exclusion Criteria:
• • 1. Extensive growth into cranial part of the sacrum (above S2/3 junction) or the lumbosacral nerve roots indicating that surgery will never be possible even if substantial tumour down-sizing is achieved.
• • 2. Presence of metastatic disease or recurrent rectal tumour.
• • 3. Presence of grade ≥1 peripheral neuropathy according to the Common Toxicity Criteria for Adverse Events (CTCAE) v.5.0.
• • 4. Significant medical, neuro-psychiatric, or surgical condition, currently uncontrolled by treatment, which, in the principal investigator's opinion, may interfere with completion of the study.
• • 5. Any contraindication to pelvic irradiation as evaluated by the investigator.
• • 6. Known hypersensitivity reactions to the study drugs or to any excipients, premedications or non-investigational medicinal products or concomitant medications.
• • 7. Any investigational anti-cancer therapy other than the protocol specified therapies (participation in other prospective studies which do not imply any specific intervention may be allowed after discussion with the Study Chair).
• • 8. Patients with a prior or concurrent malignancy whose natural history or treatment has the potential to interfere with the safety or efficacy assessment.
• • 9. Clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident/stroke, myocardial infarction, unstable angina, congestive heart failure (grade III or IV as classified by the New York Heart Association), or serious cardiac arrhythmia requiring medication within the past 6 months.
• • 10. Known complete dihydropyrimidine dehydrogenase (DPD) deficiency.
• • 11. Any previous treatment for rectal cancer.