Spatial-Motor Stroke-Rehab Study

Launched by EMORY UNIVERSITY · Sep 22, 2023

Keywords

ClinConnect Summary

The Spatial-Motor Stroke-Rehab Study is aimed at understanding how a specific type of therapy, called prism adaptation training, can help improve visual and motor skills in people who have experienced a stroke, particularly those with a condition known as spatial neglect. This study will also explore the effects of adding electrical stimulation to this training. Researchers are hoping to find ways to enhance recovery and improve walking abilities for stroke patients.

To participate in this study, individuals must be between 40 and 90 years old and have had a stroke affecting the right side of the brain at least three months ago. They should be able to walk at least 10 meters, even with help, and able to follow simple commands. The study is currently looking for both younger healthy adults (ages 18-30) and older healthy adults (ages 45-90) as well, but they must not have any physical or neurological disorders. Participants can expect to engage in training sessions, and the study will monitor their progress and the effects on their abilities. It's important to note that people with certain medical conditions or disabilities may not be eligible to participate.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Young Adults Able Bodied (YAB) Individuals
• • 18-30 years
• • Able-Bodied (healthy without any physical disability or neurological disorder)
• • Older Adults Able-Bodied Individuals (OAB)
• • 45-90 years
• • Able-Bodied (healthy without any physical disability or neurological disorder)
• • Individuals with right hemisphere stroke (40-90 years)
• • \>3 months following stroke.
• • Presence of Aiming SN
• • Ability to walk \>10m with or without assistive devices.
• • Unilateral left-sided hemiparesis with gross arm strength of ≤ grade 4/5 on the Medical Research Council Scale
• • Ability to follow 3-stage commands and provide informed consent.
• Exclusion Criteria:
• • Young Adults Able Bodied (YAB) Individuals and Older Adults Able-Bodied Individuals (OAB)
• • History or evidence of orthopedic or physical disability
• • History or evidence of neurological pathology
• • Pregnancy (female)
• • Uncontrolled hypertension
• • Cardiac pacemaker or other implanted electronic system
• • Presence of skin conditions preventing electrical stimulation setup
• • Impaired sensation in the left upper limb.
• • Bruises or cuts at the stimulation electrode placement site
• • Concurrent enrollment in rehabilitation or another investigational study.
• • History or evidence of orthopedic or physical disability interfering with study procedures
• • History or evidence of neurological pathology or disorder
• • Severe uncontrolled medical problems (e.g., hypertension, cardiovascular disease, rheumatoid arthritis, active cancer or renal disease, epilepsy) that may interfere with study procedures
• • Contraindications to TMS such as metal implants, medications that can increase cortical excitability, unexplained dizziness in the past 6 months
• • Individuals with right hemisphere stroke (40-90 years)
• • History of multiple strokes or brainstem strokes
• • Cerebellar disorders
• • Impaired sensation in the left upper limb.
• • History of other neurological disorders
• • Uncontrolled hypertension
• • Cardiac pacemaker or other implanted electronic system
• • Pregnancy (female)
• • Presence of skin condition
• • Bruises at the electrode placement site
• • Concurrent enrollment in rehabilitation or another investigational study
• • Severe uncontrolled medical problems (e.g., hypertension, cardiovascular disease, rheumatoid arthritis, active cancer or renal disease, epilepsy) or other medical conditions that can interfere with study procedures
• • Contraindications to TMS such as metal implants in the brain, medications that will increase cortical excitability, etc.