COronary CoLLateralization in Type 2 diabEtic Patients With Chronic Total Occlusion

Launched by RUIJIN HOSPITAL · Sep 19, 2023

Keywords

ClinConnect Summary

This clinical trial is looking at how well the heart develops new blood vessels (called collateral circulation) in patients with type 2 diabetes who have a complete blockage in one of their coronary arteries. The researchers want to see if these patients form these new blood vessels as effectively as those without diabetes. By studying this, the trial hopes to understand better how diabetes affects heart health and potentially improve treatment options for patients with similar conditions.

If you are between the ages of 18 and 90, have type 2 diabetes, and have at least one blocked coronary artery, you might be eligible to participate in this study. Participants will have the opportunity to undergo tests to assess their heart condition and receive close monitoring. It's important to know that individuals with severe kidney issues, advanced heart failure, or certain other health problems may not be able to join. Overall, this trial aims to gather valuable information that could help improve care for people with type 2 diabetes and heart disease.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 18-90 years
• * Type 2 diabetes diagnosed by one of the following criteria:
• • HbA1c \>/= 6.5% Fasting plasma glucose \>/= 7.0 mmol/l (confirmed) 2h plasma glucose value during OGTT \>/= 11.1 mmol/l Already receiving glucose-lowering agents.
• • At least one lesion with angiographic total occlusion
• Exclusion Criteria:
• • eGFR\<15mL/(min·1.73m2)
• • chronic heart failure with NYHA grade ≥3
• • had a history of coronary artery bypass grafting
• • had received a percutaneous coronary intervention within the prior 3 months
• • Malignant tumor or immune system disorders
• • Pulmonary heart disease