Study on Vaginal Microecology and Cervical Local Immune Function in Patients With Uterine Fibroids of Childbearing Age

Launched by LIN YUAN · Sep 23, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how uterine fibroids, which are noncancerous growths in the uterus, might affect the balance of bacteria in the vagina and the local immune response in the cervix for women of childbearing age. The researchers want to understand the connection between these factors to help improve health outcomes for women with fibroids.

To join the study, women aged 20 to 49 who are premenopausal and have been diagnosed with uterine fibroids can apply, as well as healthy women in the same age range with no history of uterine issues. Participants will undergo tests to ensure they meet the criteria, and they will need to avoid certain medications or treatments prior to their participation. While the study is not yet recruiting participants, it aims to gather valuable information that could lead to better understanding and management of uterine fibroids in the future.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• Study group inclusion criteria:
• • Age 20-49 years old
• • Premenopausal
• • Clinical diagnosis of uterine myoma
• • Cervical liquid-based cytology and human papillomavirus typing test are negative
• Healthy control group:
• • Age 20-49 years old
• • Premenopausal
• • Uterine B-ultrasonography is normal
• • Cervical liquid-based cytology and human papillomavirus typing test are negative
• • No vaginal infection
• Exclusion Criteria:
• Exclusion criteria of the study group:
• • Used antibiotics, hormones, immunosuppressants and regulators within 1 month
• • Sex, vaginal irrigation or applied medicine 3 days before the vaginal discharge sampling
• • Pregnant, lactating or menstruating women
• • Uterus and uterine adnexa have other lesions
• Exclusion criteria of healthy control group:
• • Used antibiotics, hormones, immunosuppressants and regulators within 1 month
• • Sex, vaginal irrigation or applied medicine 3 days before the vaginal discharge sampling
• • Pregnant, lactating or menstruating women