Quantitation and Spatial Registration of Airways Dysfunction With Dynamic 19F MRI in Cystic Fibrosis

Launched by UNIVERSITY OF NORTH CAROLINA, CHAPEL HILL · Sep 25, 2023

Keywords

ClinConnect Summary

This clinical trial is studying how well the lungs work in people with cystic fibrosis (CF) over the course of a year. Researchers will use a special type of MRI that involves inhaling a contrast gas to see how air moves in the lungs. They want to understand how lung function changes when patients experience a worsening of their condition, known as a pulmonary exacerbation, and how treatment might help. Participants will visit the University of North Carolina at Chapel Hill for 3 to 5 appointments, each lasting up to 4 hours, depending on whether they have an exacerbation during the year.

To be eligible for this study, participants must be at least 18 years old, non-smokers, and have mild lung disease (with a specific measurement indicating good lung function). They should be in stable health and not have had any recent lung flare-ups. Importantly, there are no known benefits for joining this trial, but it will contribute to understanding lung health in people with cystic fibrosis.

Gender

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Eligibility criteria

• Inclusion Criteria:
• • 1. Subjects must be ≥18 years of age
• • 2. Non-smokers (\<10 pack/year history and no active smoking in the past year)
• • 3. Diagnosis of cystic fibrosis via standard sweat chloride/phenotypic features/genotyping
• • 4. No use of supplemental oxygen
• • 5. Stable lung function (within 10% of personal best in the last 6 months) with no pulmonary exacerbations in the past 4 weeks and baseline FEV1≥60% of predicted
• • 6. Evidence of a personally signed and dated consent indicating that the subject has been informed of all pertinent aspects of the trial
• • 7. Subjects must be willing and able to comply with scheduled visits and other trial procedures
• Exclusion Criteria:
• Subjects presenting with any of the following will not be included in the trial:
• • 1. Active or past smokers or vapers with less than 1 year since quitting or \>10 pack-year smoking history
• • 2. Unable to undergo a 3.0-Tesla MRI exam of the lungs and chest because of contraindications including
• • 1. Occupation (past or present) of machinist, welder, or grinder;
• • 2. Injury to the eye involving a metallic object
• • 3. Injury to the body by a metallic object (bullet, bullet ball, shrapnel)
• • 4. Presence of a cardiac pacemaker or defibrillator
• • 5. Presence of aneurysm clips
• • 6. Presence of carotid artery vascular clamp
• • 7. Presence of neurostimulator
• • 8. Presence of insulin or infusion pump
• • 9. Presence of implanted drug infusion device that is not known to be MRI compatible (i.e., was placed outside of UNC or is older than 10 years)
• • 10. Bone growth or fusion simulator
• • 11. Presence of cochlear, otologic or ear implant
• • 12. Any type of prosthesis (eye, penile, etc.)
• • 13. Artificial limb or joint
• • 14. Non-removable electrodes (on body, head or brain)
• • 15. Intravascular stents, filters or coils
• • 16. Shunt (spinal or intraventricular)
• • 17. Swan-Ganz catheter
• • 18. Any implant held in place by a magnet
• • 19. Transdermal delivery system (e.g. Nitro)
• • 20. An intrauterine device or diaphragm that is not MRI compatible
• • 21. Tattooed makeup (eyeliner, lips, etc.) or tattoos covering \>25% of body surface area
• • 22. Body piercings (must be removed before MRI)
• • 23. Any metal fragments
• • 24. Internal pacing wires
• • 25. Metal or wire mesh implants
• • 26. Hearing aid (remove before MRI) aa. Dentures (remove before MRI) bb. Claustrophobia
• • 3. Unable to tolerate inhalation of gas mixture
• • 4. Presence of facial hair that may interfere with the fit of the mask (and unwillingness to shave prior to each MRI)
• • 5. Any changes in medications that may affect CF lung disease in the past 28 days, including any experimental therapies
• • 6. Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with trial participation or may interfere with the interpretation of trial results and, in the judgment of the investigator, would make the subject inappropriate for entry into this trial.
• • 7. Pregnancy; women of childbearing potential must have a confirmed negative urine pregnancy test on the day of the MR scan, prior to the MRI scan.