The Chronic Kidney Disease Adaptive Platform Trial Investigating Various Agents for Therapeutic Effect
Launched by THE GEORGE INSTITUTE · Sep 21, 2023
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
The CAPTIVATE trial is a large international study looking at different treatments for people with chronic kidney disease (CKD). The main goal of this trial is to find the best way to slow down the progression of CKD, which helps prevent more serious conditions like kidney failure. If you're an adult aged 18 or older with a known case of CKD and are currently receiving standard treatment, you might be eligible to participate in this trial.
Participants in the CAPTIVATE trial will be randomly assigned to receive different treatments or combinations of treatments. This means you may receive a treatment that is part of the study, which could help researchers learn more about what works best. It’s important to note that if you are planning to start kidney replacement therapy or have a life expectancy of less than six months, you won’t be able to join this study. Overall, this trial aims to improve treatment options for CKD and ultimately enhance the quality of life for those affected by this condition.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • 1. Age ≥ 18 years
- • 2. Known chronic kidney disease from any cause (eGFR ≥25 mL/min/1.73m2)
- • 3. Currently receiving standard of care treatment according to treating physician
- • 4. Eligible for randomisation in at least one recruiting domain-specific appendix
- • 5. Participant and treating physician are willing and able to perform trial procedures
- Exclusion Criteria:
- • 1. Planned to commence kidney replacement therapy or kidney transplant surgery in next 6 months
- • 2. Life expectancy less than 6 months
About The George Institute
The George Institute for Global Health is a leading research organization dedicated to improving health outcomes through innovative clinical trials and groundbreaking research. Based in Australia, the institute focuses on addressing major health challenges, particularly in the areas of chronic diseases, cardiovascular health, and health equity. With a commitment to translating scientific discoveries into real-world applications, The George Institute collaborates with global partners to advance knowledge and implement effective health interventions. Its multidisciplinary team of researchers employs rigorous methodologies to ensure high-quality evidence that informs policy and practice, ultimately striving to enhance public health on a global scale.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Westmead, New South Wales, Australia
Garran, Australian Capital Territory, Australia
Heidelberg, Victoria, Australia
New Lambton Heights, New South Wales, Australia
Kogarah, New South Wales, Australia
Elizabeth Vale, South Australia, Australia
Douglas, Queensland, Australia
Chennai, Tamil Nadu, India
Southport, Queensland, Australia
Birtinya, Queensland, Australia
Kolkata, West Bengal, India
Ipswich, Queensland, Australia
Visakhapatnam, Andra Pradesh, India
Wayanad, Kerala, India
Siliguri, West Bengal, India
Kingswood, New South Wales, Australia
Murdoch, Western Australia, Australia
Patna, Bihar, India
Mangaluru, Karnataka, India
Hyderabad, Kothaguda, Telangana, India
Lucknow, Uttar Pradesh, India
Dehradun, Uttarakhand, India
Anandapur, East Kolkata Township, West Bengal, India
Hastings, Hawkes Bay, New Zealand
Auckland, , New Zealand
Auckland, , New Zealand
Meppadi, Kerala, India
Indore, Madhya Pradesh, India
Hyderabad, Telangana, India
Hyderabad, Telangana, India
Patients applied
Trial Officials
Sradha Kotwal
Study Chair
The George Institute
Hiddo Lambers Heerspink
Study Chair
The George Institute
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported